Invention Grant
- Patent Title: Enantioselective synthesis of α-quaternary Mannich adducts by palladium-catalyzed allylic alkylation
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Application No.: US16579382Application Date: 2019-09-23
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Publication No.: US11377396B2Publication Date: 2022-07-05
- Inventor: Brian M. Stoltz , Yoshitaka Numajiri , Beau P. Pritchett , Koji Chiyoda
- Applicant: California Institute of Technology
- Applicant Address: US CA Pasadena
- Assignee: California Institute of Technology
- Current Assignee: California Institute of Technology
- Current Assignee Address: US CA Pasadena
- Agency: Foley Hoag LLP
- Agent Janine S. Ladislaw
- Main IPC: C07B53/00
- IPC: C07B53/00 ; C07C233/76 ; C07C271/18 ; C07C271/50 ; C07C311/16 ; C07D209/88 ; C07D211/74 ; C07D211/76 ; C07D265/32
Abstract:
This invention provides enantioenriched Mannich adducts with quaternary stereogenic centers and novel methods of preparing the compounds. Methods include the method for the preparation of a compound of formula (I): comprising treating a compound of formula (II): with a transition metal catalyst under alkylation conditions.
Public/Granted literature
- US20200157020A1 ENANTIOSELECTIVE SYNTHESIS OF ALPHA-QUATERNARY MANNICH ADDUCTS BY PALLADIUM-CATALYZED ALLYLIC ALKYLATION Public/Granted day:2020-05-21
Information query
