Invention Grant
- Patent Title: Cystine knot scaffold platform
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Application No.: US16544394Application Date: 2019-08-19
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Publication No.: US11407794B2Publication Date: 2022-08-09
- Inventor: Rami Hannoush , Harini Kaluarachchi , Aaron Nile , Cameron Noland , Yingnan Zhang , Lijuan Zhou , Xinxin Gao
- Applicant: Genentech, Inc.
- Applicant Address: US CA South San Francisco
- Assignee: Genentech, Inc.
- Current Assignee: Genentech, Inc.
- Current Assignee Address: US CA South San Francisco
- Agency: Morrison & Foerster LLP
- Main IPC: C07K14/415
- IPC: C07K14/415 ; C07K14/00 ; A61K47/34 ; A61K38/16 ; A61K9/00 ; A61K9/50 ; C07K14/47 ; C07K14/81 ; A61K38/00
Abstract:
Provided are non-naturally occurring cystine knot peptides (CKPs) that bind to VEGF-A. Additionally, provided are methods of using non-naturally occurring CKPs that bind to VEGF-A, including diagnostic and therapeutic compositions and methods. Non-naturally CKPs that bind low density lipoprotein receptor-related protein 6 (LRP6) are also provided.
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