- 专利标题: Compositions containing, methods involving, and uses of non-natural amino acid linked dolastatin derivatives
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申请号: US17142169申请日: 2021-01-05
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公开(公告)号: US11420999B2公开(公告)日: 2022-08-23
- 发明人: Zhenwei Miao , Kyle Atkinson , Sandra Biroc , Timothy Buss , Melissa Neal , Vadim Kraynov , Robin Marsden , Jason Pinkstaff , Lillian Skidmore , Ying Sun , Agnieszka Szydlik , Delia Ianina Lopez De Valenta
- 申请人: Ambrx, Inc.
- 申请人地址: US CA La Jolla
- 专利权人: Ambrx, Inc.
- 当前专利权人: Ambrx, Inc.
- 当前专利权人地址: US CA La Jolla
- 代理机构: Ambrx, Inc.
- 优先权: WOPCT/US2012/039472 20120524
- 主分类号: C07K5/10
- IPC分类号: C07K5/10 ; C07K5/103 ; C07D207/08 ; C07D401/12 ; C07D417/12 ; C07K5/02 ; A61K47/68 ; A61K38/07 ; C07K5/062
摘要:
Disclosed herein are non-natural amino acids and dolastatin analogs that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The dolastatin analogs can include a wide range of possible functionalities, but typically have at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Also disclosed herein are non-natural amino acid dolastatin analogs that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such dolastatin analogs. Typically, the modified dolastatin analogs include at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Further disclosed are methods for using such non-natural amino acid dolastatin analogs and modified non-natural amino acid dolastatin analogs, including therapeutic, diagnostic, and other biotechnology use.