Invention Grant
- Patent Title: Optimization of multigene analysis of tumor samples
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Application No.: US16245301Application Date: 2019-01-11
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Publication No.: US11421265B2Publication Date: 2022-08-23
- Inventor: Doron Lipson , Geoffrey Alan Otto , Alexander Nevin Parker , Philip James Stephens , Sean R. Downing , Mima Jarosz , Mikhail G. Shapiro , Roman Yelensky
- Applicant: FOUNDATION MEDICINE, INC.
- Applicant Address: US MA Cambridge
- Assignee: FOUNDATION MEDICINE, INC.
- Current Assignee: FOUNDATION MEDICINE, INC.
- Current Assignee Address: US MA Cambridge
- Agency: Morrison & Foerster LLP
- Main IPC: C12Q1/6827
- IPC: C12Q1/6827 ; C12Q1/6874 ; C12Q1/6886 ; G16B20/10 ; G16B30/10 ; G16B20/20 ; G16B20/00 ; G16B30/00

Abstract:
A method of analyzing a tumor sample comprising: (a) acquiring a library comprising a plurality of tumor members from a tumor sample; (b) contacting the library with a bait set to provide selected members; (c) acquiring a read for a subgenomic interval from a tumor member from said library; (d) aligning said read; and (e) assigning a nucleotide value (e.g., calling a mutation) from said read for the preselected nucleotide position, thereby analyzing said tumor sample.
Public/Granted literature
- US20190136301A1 OPTIMIZATION OF MULTIGENE ANALYSIS OF TUMOR SAMPLES Public/Granted day:2019-05-09
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