-
公开(公告)号：US12180540B2
公开(公告)日：2024-12-31
申请号：US17812415
申请日：2022-07-13
Applicant: Foundation Medicine, Inc.
Inventor： Doron Lipson , Geoffrey Alan Otto , Alexander Nevin Parker , Philip James Stephens , Sean R. Downing , Mirna Jarosz , Mikhail G. Shapiro , Roman Yelensky
IPC: C12Q1/6827 , C12Q1/6874 , C12Q1/6886 , G16B20/00 , G16B20/10 , G16B20/20 , G16B30/00 , G16B30/10
Abstract: A method of analyzing a tumor sample comprising: (a) acquiring a library comprising a plurality of tumor members from a tumor sample; (b) contacting the library with a bait set to provide selected members; (c) acquiring a read for a subgenomic interval from a tumor member from said library; (d) aligning said read; and (e) assigning a nucleotide value (e.g., calling a mutation) from said read for the preselected nucleotide position, thereby analyzing said tumor sample.
-
公开(公告)号：US20180280391A1
公开(公告)日：2018-10-04
申请号：US15839560
申请日：2017-12-12
Applicant: FOUNDATION MEDICINE, INC.
Inventor： Sean R. Downing , Matthew J. Hawryluk , Doron Lipson , Alexander N. Parker , Philip James Stephens
IPC: A61K31/517 , C12N15/113 , A61K31/513 , C07K14/82 , A61K31/4412 , A61K31/404 , A61K31/47 , C12Q1/6886 , C12N9/14 , A61K31/444
Abstract: Novel RET fusion molecules and uses are disclosed.
-
公开(公告)号：US09861633B2
公开(公告)日：2018-01-09
申请号：US14333368
申请日：2014-07-16
Applicant: FOUNDATION MEDICINE, INC.
Inventor： Siraj Mahamed Ali , Matthew J. Hawryluk , Jeffrey S. Ross , Philip James Stephens
IPC: C12Q1/68 , A61K31/517 , A61K47/48 , A61K31/5365 , C07K14/82 , C07K16/32 , A61K45/06 , A61K31/475 , A61K31/519 , A61K31/704 , A61K31/7105 , A61K31/713 , A61K33/24
CPC classification number: A61K31/517 , A61K31/475 , A61K31/519 , A61K31/5365 , A61K31/704 , A61K31/7105 , A61K31/713 , A61K33/24 , A61K45/06 , A61K47/6803 , A61K47/6851 , A61K47/6855 , C07K14/82 , C07K16/32 , C12Q1/6886 , C12Q2600/106 , A61K2300/00
Abstract: Methods and compositions for treating a urothelial and/or a micropapillary carcinoma, such as a micropapillary urothelial carcinoma are disclosed.
-
公开(公告)号：US20160145691A1
公开(公告)日：2016-05-26
申请号：US14753397
申请日：2015-06-29
Applicant: FOUNDATION MEDICINE, INC.
Inventor： Maureen T. Cronin , Garrett Michael Frampton , Doron Lipson , Vincent A. Miller , Gary Palmer , Jeffrey S. Ross , Philip James Stephens , Roman Yelensky
IPC: C12Q1/68 , A61K45/06 , C07K16/28 , C07K14/72 , A61K31/5415 , A61K31/437 , A61K31/423 , A61K31/428 , A61K31/472 , A61K31/536 , A61K31/416 , A61K31/4439
CPC classification number: C12Q1/6886 , A61K31/416 , A61K31/4196 , A61K31/423 , A61K31/428 , A61K31/436 , A61K31/437 , A61K31/439 , A61K31/4439 , A61K31/472 , A61K31/536 , A61K31/5415 , A61K31/565 , A61K31/567 , A61K31/675 , A61K45/06 , C07K14/72 , C07K16/2869 , C07K2317/34 , C12Q2600/106 , C12Q2600/118 , C12Q2600/156
Abstract: Novel mutant ESR1 molecules and uses are disclosed.
Abstract translation: 公开了新型突变体ESR1分子和用途。
-
公开(公告)号：US20140037622A1
公开(公告)日：2014-02-06
申请号：US13958502
申请日：2013-08-02
Applicant: UCL Business PLC , FOUNDATION MEDICINE, INC.
Inventor： Chris Hendrik Boshoff , Timothy Robert Fenton , Matthias Alexander Lechner , Philip James Stephens , Matthew J. Hawryluk , Roman Yelensky , Garrett Michael Frampton
IPC: C12Q1/70 , A61K31/519 , A61K31/454 , A61K31/52 , A61K31/404 , A61K31/4196 , A61K33/24 , A61K31/282 , A61K31/337 , A61K31/513 , A61K39/395 , A61K31/436 , A61K31/05 , A61K31/4709 , A61K31/496 , A61K31/5377 , A61K31/352 , A61N5/00 , A61K31/506
CPC classification number: A61K31/519 , A61K31/05 , A61K31/282 , A61K31/337 , A61K31/352 , A61K31/366 , A61K31/404 , A61K31/4196 , A61K31/436 , A61K31/439 , A61K31/454 , A61K31/4709 , A61K31/4745 , A61K31/496 , A61K31/505 , A61K31/506 , A61K31/513 , A61K31/52 , A61K31/5377 , A61K31/555 , A61K33/24 , A61K39/39558 , A61K2039/505 , A61N5/00 , A61N5/10 , C07K16/2863 , C12Q1/6883 , C12Q1/6886 , C12Q1/708 , C12Q2600/106 , C12Q2600/118 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , G01N33/571 , A61K2300/00
Abstract: Methods of treating a head and neck cancer are disclosed.
Abstract translation: 公开了治疗头颈癌的方法。
-
Patent Agency Ranking
公开(公告)号：US10980804B2
公开(公告)日：2021-04-20
申请号：US14761518
申请日：2014-01-17
Applicant: FOUNDATION MEDICINE, INC.
Inventor： Siraj Mahamed Ali , Matthew J. Hawryluk , Jie He , Doron Lipson , Vincent A. Miller , Jeffrey S. Ross , Philip James Stephens
IPC: A61K31/517 , A61K31/498 , A61K31/19 , A61K31/5025 , C12N9/12 , A61K31/4412 , A61K45/06 , A61K31/47 , A61K31/435 , A61K31/506 , A61K31/519 , A61K31/4439 , A61K31/53 , A61K31/404 , A61K31/5383 , A61K31/496 , C12Q1/6886 , A61K31/553 , C07K14/705 , C07K14/71 , C07K16/40 , C12N15/113 , C12Q1/6883 , G01N33/573
Abstract: Methods and compositions for treating cholangiocarcinoma.
-
公开(公告)号：US20200294668A1
公开(公告)日：2020-09-17
申请号：US16793405
申请日：2020-02-18
Applicant: FOUNDATION MEDICINE, INC.
Inventor： Michael Pellini , Gary Palmer , Mary Patricia Lancelotta , Matthew J. Hawryluk , Philip James Stephens
Abstract: Various embodiments provide interfaces to access genomic testing information and incorporate it into daily physician practice. In some embodiments, presentation of genomic alteration data is simplified and/or coupled with contextual applications. Volumes of genomic alterations and associated information (e.g., journal articles, clinical trial information, therapies, etc.) are analyzed and synthesized into actionable information items viewable on an alteration system. According to one embodiment, the system can be configured to focus practitioners on discrete portions of the alteration information on which they can act. According to other aspects, curated information is provided on the system to enable practitioners to make informed decisions regarding the implications of the presence of specific genomic alterations.
-
公开(公告)号：US20200281930A1
公开(公告)日：2020-09-10
申请号：US16654582
申请日：2019-10-16
Applicant: FOUNDATION MEDICINE, INC. , UCL Business PLC
Inventor： Chris Hendrik Boshoff , Timothy Robert Fenton , Matthias Alexander Lechner , Philip James Stephens , Matthew J. Hawryluk , Garrett Michael Frampton , Roman Yelensky
IPC: A61K31/519 , C12Q1/70 , A61K31/506 , A61K31/454 , A61K31/52 , A61K31/404 , A61K31/4196 , A61K33/24 , A61K31/282 , A61K31/337 , A61K31/513 , A61K39/395 , A61K31/436 , A61K31/05 , A61K31/4709 , A61K31/496 , A61K31/5377 , A61K31/352 , A61N5/00 , C12Q1/6886 , A61K31/366 , A61K31/505 , A61K31/555 , A61K31/439 , A61K31/4745 , C07K16/28 , C12Q1/6883 , G01N33/571 , A61N5/10
Abstract: Methods of treating a head and neck cancer are disclosed.
-
公开(公告)号：US09884060B2
公开(公告)日：2018-02-06
申请号：US15045716
申请日：2016-02-17
Applicant: FOUNDATION MEDICINE, INC.
Inventor： Sean R. Downing , Matthew J. Hawryluk , Doron Lipson , Alexander N. Parker , Philip James Stephens
IPC: A61K31/517 , C07K14/82 , C12N9/14 , C12Q1/68 , A61K31/404 , A61K31/4412 , A61K31/444 , A61K31/47 , A61K31/513 , C12N15/113
CPC classification number: A61K31/517 , A61K31/404 , A61K31/4412 , A61K31/444 , A61K31/47 , A61K31/513 , C07K14/82 , C07K2319/00 , C12N9/14 , C12N15/1135 , C12Q1/6886 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158
Abstract: Novel RET fusion molecules and uses are disclosed. In one embodiment, a KIF5B-RET fusion includes an in-frame fusion of an exon of KIF5B (e.g., one or more exons encoding a kinesin motor domain or a fragment thereof) and an exon of RET (e.g., one or more exons encoding a RET tyrosine kinase domain or a fragment thereof). For example, the KIF5B-RET fusion can include an in-frame fusion of at least exon 15 of KIF5B or a fragment thereof (e.g., exons 1-15 of KIF5B or a fragment thereof) with at least exon 12 of RET or a fragment thereof (e.g., exons 12-20 of RET or a fragment thereof).
-
公开(公告)号：US20180000820A1
公开(公告)日：2018-01-04
申请号：US15433646
申请日：2017-02-15
Applicant: FOUNDATION MEDICINE, INC.
Inventor： Siraj Mahamed Ali , Matthew J. Hawryluk , Jeffrey S. Ross , Philip James Stephens
IPC: A61K31/517 , C12Q1/68 , C07K16/32 , C07K14/82 , A61K45/06 , A61K31/475 , A61K47/68 , A61K31/7105 , A61K31/704 , A61K31/5365 , A61K31/519 , A61K31/713 , A61K33/24
CPC classification number: A61K31/517 , A61K31/475 , A61K31/519 , A61K31/5365 , A61K31/704 , A61K31/7105 , A61K31/713 , A61K33/24 , A61K45/06 , A61K47/6803 , A61K47/6851 , A61K47/6855 , C07K14/82 , C07K16/32 , C12Q1/6886 , C12Q2600/106 , A61K2300/00
Abstract: Methods and compositions for treating a urothelial and/or a micropapillary carcinoma, such as a micropapillary urothelial carcinoma are disclosed.
-
-
-
-
-
-
-
-
-
Search Results
47
records
(took 0.032 seconds)
