公开(公告)号：US20170014413A1

公开(公告)日：2017-01-19

申请号：US15045716

申请日：2016-02-17

Applicant: FOUNDATION MEDICINE, INC.

Inventor： Sean R. Downing ,  Matthew J. Hawryluk ,  Doron Lipson ,  Alexander N. Parker ,  Philip James Stephens

IPC: A61K31/517 ,  A61K31/47 ,  A61K31/513 ,  A61K31/4412 ,  A61K31/404

CPC classification number: A61K31/517 ,  A61K31/404 ,  A61K31/4412 ,  A61K31/444 ,  A61K31/47 ,  A61K31/513 ,  C07K14/82 ,  C07K2319/00 ,  C12N9/14 ,  C12N15/1135 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/156 ,  C12Q2600/158

Abstract: Novel RET fusion molecules and uses are disclosed. In one embodiment, a KIF5B-RET fusion includes an in-frame fusion of an exon of KIF5B (e.g., one or more exons encoding a kinesin motor domain or a fragment thereof) and an exon of RET (e.g., one or more exons encoding a RET tyrosine kinase domain or a fragment thereof). For example, the KIF5B-RET fusion can include an in-frame fusion of at least exon 15 of KIF5B or a fragment thereof (e.g., exons 1-15 of KIF5B or a fragment thereof) with at least exon 12 of RET or a fragment thereof (e.g., exons 12-20 of RET or a fragment thereof).

Abstract translation: 公开了新型RET融合分子和用途。 在一个实施方案中，KIF5B-RET融合包括KIF5B的外显子（例如，编码驱动蛋白运动区或其片段的一个或多个外显子）和RET的外显子（例如，一个或多个外显子编码 RET酪氨酸激酶结构域或其片段）。 例如，KIF5B-RET融合可以包括至少外显子15的KIF5B或其片段（例如，KIF5B的外显子1-15或其片段）与至少外显子12的RET或片段的片段内融合 （例如，RET的外显子12-20或其片段）。

公开(公告)号：US09884060B2

公开(公告)日：2018-02-06

申请号：US15045716

申请日：2016-02-17

Applicant: FOUNDATION MEDICINE, INC.

Inventor： Sean R. Downing ,  Matthew J. Hawryluk ,  Doron Lipson ,  Alexander N. Parker ,  Philip James Stephens

IPC: A61K31/517 ,  C07K14/82 ,  C12N9/14 ,  C12Q1/68 ,  A61K31/404 ,  A61K31/4412 ,  A61K31/444 ,  A61K31/47 ,  A61K31/513 ,  C12N15/113

CPC classification number: A61K31/517 ,  A61K31/404 ,  A61K31/4412 ,  A61K31/444 ,  A61K31/47 ,  A61K31/513 ,  C07K14/82 ,  C07K2319/00 ,  C12N9/14 ,  C12N15/1135 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/156 ,  C12Q2600/158

Abstract: Novel RET fusion molecules and uses are disclosed. In one embodiment, a KIF5B-RET fusion includes an in-frame fusion of an exon of KIF5B (e.g., one or more exons encoding a kinesin motor domain or a fragment thereof) and an exon of RET (e.g., one or more exons encoding a RET tyrosine kinase domain or a fragment thereof). For example, the KIF5B-RET fusion can include an in-frame fusion of at least exon 15 of KIF5B or a fragment thereof (e.g., exons 1-15 of KIF5B or a fragment thereof) with at least exon 12 of RET or a fragment thereof (e.g., exons 12-20 of RET or a fragment thereof).

公开(公告)号：US09297011B2

公开(公告)日：2016-03-29

申请号：US14187280

申请日：2014-02-23

Applicant: FOUNDATION MEDICINE, INC.

Inventor： Sean R. Downing ,  Matthew J. Hawryluk ,  Doron Lipson ,  Alexander N. Parker ,  Philip James Stephens

IPC: A61K31/47 ,  A61K31/517 ,  C12N15/113 ,  C07K14/82 ,  C12N9/14 ,  C12Q1/68 ,  A61K31/404 ,  A61K31/4412 ,  A61K31/444 ,  A61K31/513

CPC classification number: A61K31/517 ,  A61K31/404 ,  A61K31/4412 ,  A61K31/444 ,  A61K31/47 ,  A61K31/513 ,  C07K14/82 ,  C07K2319/00 ,  C12N9/14 ,  C12N15/1135 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/156 ,  C12Q2600/158

Abstract: Novel RET fusion molecules and uses are disclosed.

Abstract translation: 公开了新型RET融合分子和用途。

公开(公告)号：US12180540B2

公开(公告)日：2024-12-31

申请号：US17812415

申请日：2022-07-13

Applicant: Foundation Medicine, Inc.

Inventor： Doron Lipson ,  Geoffrey Alan Otto ,  Alexander Nevin Parker ,  Philip James Stephens ,  Sean R. Downing ,  Mirna Jarosz ,  Mikhail G. Shapiro ,  Roman Yelensky

IPC: C12Q1/6827 ,  C12Q1/6874 ,  C12Q1/6886 ,  G16B20/00 ,  G16B20/10 ,  G16B20/20 ,  G16B30/00 ,  G16B30/10

Abstract: A method of analyzing a tumor sample comprising: (a) acquiring a library comprising a plurality of tumor members from a tumor sample; (b) contacting the library with a bait set to provide selected members; (c) acquiring a read for a subgenomic interval from a tumor member from said library; (d) aligning said read; and (e) assigning a nucleotide value (e.g., calling a mutation) from said read for the preselected nucleotide position, thereby analyzing said tumor sample.

公开(公告)号：US20180280391A1

公开(公告)日：2018-10-04

申请号：US15839560

申请日：2017-12-12

Applicant: FOUNDATION MEDICINE, INC.

Inventor： Sean R. Downing ,  Matthew J. Hawryluk ,  Doron Lipson ,  Alexander N. Parker ,  Philip James Stephens

IPC: A61K31/517 ,  C12N15/113 ,  A61K31/513 ,  C07K14/82 ,  A61K31/4412 ,  A61K31/404 ,  A61K31/47 ,  C12Q1/6886 ,  C12N9/14 ,  A61K31/444

Abstract: Novel RET fusion molecules and uses are disclosed.

公开(公告)号：US12239648B2

公开(公告)日：2025-03-04

申请号：US17817619

申请日：2022-08-04

Applicant: Foundation Medicine, Inc.

Inventor： Sean R. Downing ,  Matthew J. Hawryluk ,  Doron Lipson ,  Alexander N. Parker ,  Philip James Stephens

IPC: A61K31/517 ,  A61K31/404 ,  A61K31/4412 ,  A61K31/444 ,  A61K31/47 ,  A61K31/513 ,  C07K14/82 ,  C12N9/14 ,  C12N15/113 ,  C12Q1/6886

Abstract: Novel RET fusion molecules and uses are disclosed.

公开(公告)号：US11421265B2

公开(公告)日：2022-08-23

申请号：US16245301

申请日：2019-01-11

Applicant: FOUNDATION MEDICINE, INC.

Inventor： Doron Lipson ,  Geoffrey Alan Otto ,  Alexander Nevin Parker ,  Philip James Stephens ,  Sean R. Downing ,  Mima Jarosz ,  Mikhail G. Shapiro ,  Roman Yelensky

IPC: C12Q1/6827 ,  C12Q1/6874 ,  C12Q1/6886 ,  G16B20/10 ,  G16B30/10 ,  G16B20/20 ,  G16B20/00 ,  G16B30/00

Abstract: A method of analyzing a tumor sample comprising: (a) acquiring a library comprising a plurality of tumor members from a tumor sample; (b) contacting the library with a bait set to provide selected members; (c) acquiring a read for a subgenomic interval from a tumor member from said library; (d) aligning said read; and (e) assigning a nucleotide value (e.g., calling a mutation) from said read for the preselected nucleotide position, thereby analyzing said tumor sample.

公开(公告)号：US20190119733A1

公开(公告)日：2019-04-25

申请号：US16178101

申请日：2018-11-01

Applicant: FOUNDATION MEDICINE, INC.

Inventor： Doron Lipson ,  Geoffrey Alan Otto ,  Alexander Nevin Parker ,  Philip James Stephens ,  Sean R. Downing ,  Mirna Jarosz ,  Mikhail G. Shapiro ,  Roman Yelensky

IPC: C12Q1/6827 ,  C12Q1/6874

Abstract: A method of analyzing a tumor sample comprising: (a) acquiring a library comprising a plurality of tumor members from a tumor sample; (b) contacting the library with a bait set to provide selected members; (c) acquiring a read for a subgenomic interval from a tumor member from said library; (d) aligning said read; and (e) assigning a nucleotide value (e.g., calling a mutation) from said read for the preselected nucleotide position, thereby analyzing said tumor sample.

公开(公告)号：US11136619B2

公开(公告)日：2021-10-05

申请号：US16178101

申请日：2018-11-01

Applicant: FOUNDATION MEDICINE, INC.

Inventor： Doron Lipson ,  Geoffrey Alan Otto ,  Alexander Nevin Parker ,  Philip James Stephens ,  Sean R. Downing ,  Mima Jarosz ,  Mikhail G. Shapiro ,  Roman Yelensky

IPC: C12Q1/6827 ,  C12Q1/6874 ,  C12Q1/6886 ,  G16B20/00 ,  G16B30/00

Abstract: A method of analyzing a tumor sample comprising: (a) acquiring a library comprising a plurality of tumor members from a tumor sample; (b) contacting the library with a bait set to provide selected members; (c) acquiring a read for a subgenomic interval from a tumor member from said library; (d) aligning said read; and (e) assigning a nucleotide value (e.g., calling a mutation) from said read for the preselected nucleotide position, thereby analyzing said tumor sample.

公开(公告)号：US11118213B2

公开(公告)日：2021-09-14

申请号：US15897824

申请日：2018-02-15

Applicant: FOUNDATION MEDICINE, INC.

Inventor： Doron Lipson ,  Geoffrey Alan Otto ,  Alexander N. Parker ,  Philip James Stephens ,  Sean R. Downing ,  Mirna Jarosz ,  Mikhail G. Shapiro ,  Roman Yelensky

IPC: C12Q1/6827 ,  C12Q1/6874 ,  C12Q1/6886 ,  G16B20/00 ,  G16B30/00

Abstract: A method of analyzing a tumor sample comprising: (a) acquiring a library comprising a plurality of tumor members from a tumor sample; (b) contacting the library with a bait set to provide selected members; (c) acquiring a read for a subgenomic interval from a tumor member from said library; (d) aligning said read; and (e) assigning a nucleotide value (e.g., calling a mutation) from said read for the preselected nucleotide position, thereby analyzing said tumor sample.