- 专利标题： Glypican-3-binding fibronectin based scaffold molecules
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申请号： US16751788申请日： 2020-01-24
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公开(公告)号： US11524992B2公开(公告)日： 2022-12-13
- 发明人: Dasa Lipovsek , Joseph Toth , Ginger C. Rakestraw , Irvith M. Carvajal , Stanley Richard Krystek, Jr. , Steven R. O'Neil , Guodong Chen , Richard Y. Huang , Bryan C. Barnhart , John Thomas Loffredo , Christina Terragni
- 申请人： BRISTOL-MYERS SQUIBB COMPANY
- 申请人地址： US NJ Princeton
- 专利权人： BRISTOL-MYERS SQUIBB COMPANY
- 当前专利权人： BRISTOL-MYERS SQUIBB COMPANY
- 当前专利权人地址： US NJ Princeton
- 代理机构： Nelson Mullins Riley & Scarborough LLP
- 代理商 Jane E. Remillard, Esq.; Cynthia L. Kanik
- 主分类号： C07K14/78
- IPC分类号： C07K14/78 ; A61K47/64 ; G01N33/68 ; A61K38/00 ; A61K47/60
摘要：
Provided herein are polypeptides which include tenth fibronectin type III domains (10Fn3) that bind to glypican-3. Also provided are fusion molecules comprising a 10Fn3 domain that bind to glypican-3 for use in diagnostic and therapeutic applications. Glypican-3 10Fn3 drug conjugates are also provided.
公开/授权文献
- US20200262893A1 GLYPICAN-3-BINDING FIBRONECTIN BASED SCAFFOLD MOLECULES 公开/授权日：2020-08-20
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