- 专利标题： System for identification of antigens recognized by T cell receptors expressed on tumor infiltrating lymphocytes
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申请号： US17252222申请日： 2019-06-14
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公开(公告)号： US11603565B2公开(公告)日： 2023-03-14
- 发明人: Nelson R. Alexander , Aoune Barhoumi , Jan Berka , Rui Chen , Lisa L. Gallegos , Toumy Guettouche , Seoyoung Kim , Maeve E. O'Huallachain , Sedide Ozturk , Jigar Patel , Florian Rubelt , Stacey Stanislaw
- 申请人： Roche Sequencing Solutions, Inc. , Ventana Medical Systems, Inc.
- 申请人地址： US CA Pleasanton; US AZ Tucson
- 专利权人： Roche Sequencing Solutions, Inc.,Ventana Medical Systems, Inc.
- 当前专利权人： Roche Sequencing Solutions, Inc.,Ventana Medical Systems, Inc.
- 当前专利权人地址： US CA Pleasanton; US AZ Tucson
- 代理商 Eric Grant Lee; Olga Kay
- 国际申请： PCT/EP2019/065717 WO 20190614
- 国际公布： WO2019/238939 WO 20191219
- 主分类号： C12Q1/6883
- IPC分类号： C12Q1/6883 ; C12N15/10 ; C12Q1/6806 ; C12Q1/6881
摘要：
The invention is a method of identifying a cognate antigen for a T-cell receptor using neoantigens from a patient's tumor cells combined with the patient's T-cells and using cell sorting, genome sequencing, expressing TCR genes, presenting tumor neoantigens on MHC complex and uniquely barcoding the T-cells where TCR recognition occurs to tag all components of the TCR recognition complex.
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