Invention Grant
- Patent Title: Aryl-n-aryl derivatives for treating a RNA virus infection
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Application No.: US17259483Application Date: 2019-07-09
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Publication No.: US11739073B2Publication Date: 2023-08-29
- Inventor: Didier Scherrer , Jamal Tazi , Florence Mahuteau-Betzer , Romain Najman , Julien Santo , Cécile Apolit
- Applicant: ABIVAX , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , UNIVERSITE DE MONTPELLIER , INSTITUT CURIE
- Applicant Address: FR Paris
- Assignee: ABIVAX,CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE,UNIVERSITE DE MONTPELLIER,INSTITUT CURIE
- Current Assignee: ABIVAX,CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE,UNIVERSITE DE MONTPELLIER,INSTITUT CURIE
- Current Assignee Address: FR Paris; FR Paris; FR Montpellier; FR Paris
- Agency: Oliff PLC
- Priority: EP 305911 2018.07.09
- International Application: PCT/EP2019/068460 2019.07.09
- International Announcement: WO2020/011811A 2020.01.16
- Date entered country: 2021-01-11
- Main IPC: C07D401/12
- IPC: C07D401/12 ; C07C237/40 ; C07C255/50 ; C07C311/16 ; C07D205/04 ; C07D213/74 ; C07D213/81 ; C07D405/12 ; C07D413/12 ; C07F7/18 ; A61P31/12 ; C07C233/65 ; C07D213/38 ; C07D213/75 ; C07D239/42 ; C07D241/12 ; C07D239/16 ; C07D239/22 ; C07D403/12

Abstract:
A compound:
wherein X1 represents an alkenylene group, a —NH—CO— group, a —CO—NH— group, Y1 represents an aryl group selected from pyridyl, pyrazinyl or pyrimidinyl, X2 represents —O—, —CO—NH—, —NH—CO—NH—, —OCH2—, —NH—CO—, a divalent 5-membered heteroaromatic ring comprising 1 to 4 heteroatoms or —SO2—NH—, and Y2 represents a hydrogen atom, a hydroxyl group, a morpholinyl group, a piperidinyl group, optionally substituted by a (C1-C4)alkyl group, a piperazinyl group, optionally substituted by a (C1-C4)alkyl group, or —CR1R2R3 or alternatively X2—Y2 represents —CONRcRd, wherein Rc and Rd form, together with the nitrogen atom a heterocyclic ring, optionally substituted by one or two (C1-C4)alkyl group, by a cyclopentyl group thus forming a spirocyclopentyl, or by a trifluoromethyl group, or any of its pharmaceutically acceptable salt, for use in the treatment and/or prevention of a RNA virus infection caused by a RNA virus belonging to group IV or V of the Baltimore classification.
wherein X1 represents an alkenylene group, a —NH—CO— group, a —CO—NH— group, Y1 represents an aryl group selected from pyridyl, pyrazinyl or pyrimidinyl, X2 represents —O—, —CO—NH—, —NH—CO—NH—, —OCH2—, —NH—CO—, a divalent 5-membered heteroaromatic ring comprising 1 to 4 heteroatoms or —SO2—NH—, and Y2 represents a hydrogen atom, a hydroxyl group, a morpholinyl group, a piperidinyl group, optionally substituted by a (C1-C4)alkyl group, a piperazinyl group, optionally substituted by a (C1-C4)alkyl group, or —CR1R2R3 or alternatively X2—Y2 represents —CONRcRd, wherein Rc and Rd form, together with the nitrogen atom a heterocyclic ring, optionally substituted by one or two (C1-C4)alkyl group, by a cyclopentyl group thus forming a spirocyclopentyl, or by a trifluoromethyl group, or any of its pharmaceutically acceptable salt, for use in the treatment and/or prevention of a RNA virus infection caused by a RNA virus belonging to group IV or V of the Baltimore classification.
Public/Granted literature
- US20210300871A1 ARYL-N-ARYL DERIVATIVES FOR TREATING A RNA VIRUS INFECTION Public/Granted day:2021-09-30
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