Invention Grant
- Patent Title: Coaxial introduction of calibrant in a flow path with analyte to an ion source
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Application No.: US17230793Application Date: 2021-04-14
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Publication No.: US11764049B2Publication Date: 2023-09-19
- Inventor: Michael O. Fogwill , Joseph D. Michienzi , Sylvain Gilles Cormier
- Applicant: Waters Technologies Corporation
- Applicant Address: US MA Milford
- Assignee: Waters Technologies Corporation
- Current Assignee: Waters Technologies Corporation
- Current Assignee Address: US MA Milford
- Agency: Goodwin Procter LLP
- Main IPC: H01J49/00
- IPC: H01J49/00 ; H01J49/04 ; G01N30/72 ; H01J49/16

Abstract:
Exemplary embodiments may deploy a valve that introduces a sample of a calibrant coaxially with flow exiting a source of a mobile phase flow, such as a liquid chromatography (LC) column, on a path to an ion source for the mass spectrometer (MS). The valve may be positioned remotely on a branch that has a junction with the path leading form the source of the mobile phase flow to the ion source. Alternatively, the valve may be positioned in line on the flow path from the source of the mobile phase flow to the ion source of the MS. A novel five port valve design may be employed. With this valve design, a first position of the valve allows a sample loop for the calibrant to be filled. In a second position, the calibrant is added coaxially to the flow from the source of the mobile phase to the MS. In a third position of the valve, diversion of or infusion to a post-source flow is enabled.
Public/Granted literature
- US20210319995A1 COAXIAL INTRODUCTION OF CALIBRANT IN A FLOW PATH WITH ANALYTE TO AN ION SOURCE Public/Granted day:2021-10-14
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