- Patent Title: High capacity composite depth filter media with low extractables
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Application No.: US17819969Application Date: 2022-08-16
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Publication No.: US11772020B2Publication Date: 2023-10-03
- Inventor: Maybelle Woo , David Yavorsky , John Amara , Nripen Singh , Kwok-Shun Cheng
- Applicant: EMD Millipore Corporation
- Applicant Address: US MA Burlington
- Assignee: EMD Millipore Corporation
- Current Assignee: EMD Millipore Corporation
- Current Assignee Address: US MA Burlington
- Agency: EMD Millipore Corporation
- Agent David J. Wilson
- Main IPC: B01D39/16
- IPC: B01D39/16 ; B01D29/66

Abstract:
A depth filtration device for the clarification of biological fluids including a composite depth filter media having a nonwoven first layer integral with a second layer containing a polyacrylonitrile (PAN) fibers, a filter aid, and a wet-strength resin. The depth filter media exhibits increased binding capacity for soluble impurities such as DNA and host cell proteins from biological/cell culture feedstreams during secondary clarification and low-level impurity clearance of harvested cell culture fluids, such as those used for the manufacture of monoclonal antibodies. The depth filter media additionally exhibits significantly lower flushing requirements, resulting in lower levels of organic, inorganic and bioburden extractables released, high dirt holding capacities and good chemical and/or radiation resistance.
Public/Granted literature
- US20220387917A1 HIGH CAPACITY COMPOSITE DEPTH FILTER MEDIA WITH LOW EXTRACTABLES Public/Granted day:2022-12-08
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