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    High capacity composite depth filter media with low extractables
    3.
    发明授权
    High capacity composite depth filter media with low extractables 有权

    公开(公告)号：US11590439B2

    公开(公告)日：2023-02-28

    申请号：US14890774

    申请日：2014-09-02

    申请人： EMD Millipore Corporation

    发明人： Maybelle Woo ,  David Yavorksy ,  John Amara ,  Nripen Singh ,  Kwok-Shun Cheng

    IPC分类号： B01D39/16 ,  B01D29/66

    摘要： A depth filtration device for the clarification of biological fluids including a composite depth filter media having a nonwoven first layer integral with a second layer containing a polyaeryionitrile (PAN) fibers, a filter aid, and a wet-strength resin. The depth filter media exhibits increased creased binding capacity for soluble impurities such as DNA and host eel! proteins from biological/cell culture feed-streams during secondary clarification and low-level impurity clearance of harvested cell culture fluids, such as those used for the manufacture of monoclonal antibodies. The depth filter media additionally exhibits significantly lower flushing requirements, resulting in lower levels of organic, inorganic and bioburden extractables released, high dirt holding capacities and good chemical and/or radiation resistance.

    High capacity composite depth filter media with low extractables
    4.
    发明授权
    High capacity composite depth filter media with low extractables 有权

    公开(公告)号：US11439933B2

    公开(公告)日：2022-09-13

    申请号：US16720102

    申请日：2019-12-19

    申请人： EMD Millipore Corporation

    发明人： Maybelle Woo ,  David Yavorsky ,  John Amara ,  Nripen Singh ,  Kwok-Shun Cheng

    IPC分类号： B01D39/16 ,  B01D29/66

    摘要： A depth filtration device for the clarification of biological fluids including a composite depth filter media having a nonwoven first layer integral with a second layer containing a polyacrylonitrile (PAN) fibers, a filter aid, and a wet-strength resin. The depth filter media exhibits increased binding capacity for soluble impurities such as DNA and host cell proteins from biological/cell culture feedstreams during secondary clarification and low-level impurity clearance of harvested cell culture fluids, such as those used for the manufacture of monoclonal antibodies. The depth filter media additionally exhibits significantly lower flushing requirements, resulting in lower levels of organic, inorganic and bioburden extractables released, high dirt holding capacities and good chemical and/or radiation resistance.

    HIGH CAPACITY COMPOSITE DEPTH FILTER MEDIA WITH LOW EXTRACTABLES
    9.
    发明申请
    HIGH CAPACITY COMPOSITE DEPTH FILTER MEDIA WITH LOW EXTRACTABLES 有权

    公开(公告)号：US20220387917A1

    公开(公告)日：2022-12-08

    申请号：US17819969

    申请日：2022-08-16

    申请人： EMD Millipore Corporation

    发明人： Maybelle Woo ,  David Yavorsky ,  John Amara ,  Nripen Singh ,  Kwok-Shun Cheng

    IPC分类号： B01D39/16 ,  B01D29/66

    摘要： A depth filtration device for the clarification of biological fluids including a composite depth filter media having a nonwoven first layer integral with a second layer containing a polyacrylonitrile (PAN) fibers, a filter aid, and a wet-strength resin. The depth filter media exhibits increased binding capacity for soluble impurities such as DNA and host cell proteins from biological/cell culture feedstreams during secondary clarification and low-level impurity clearance of harvested cell culture fluids, such as those used for the manufacture of monoclonal antibodies. The depth filter media additionally exhibits significantly lower flushing requirements, resulting in lower levels of organic, inorganic and bioburden extractables released, high dirt holding capacities and good chemical and/or radiation resistance.