This document describes apparatuses and techniques for termination for single-ended (SE) mode operation of a memory device. In various aspects, a termination circuit can terminate an unused signal line of a differential pair to a ground or power rail using a switch element when operating in the SE mode. The termination circuit may also disconnect the unused signal line from a first input of a differential amplifier and connect a reference voltage to the first input of the differential amplifier. Based on the reference voltage, the differential amplifier amplifies an SE signal received using another signal line of the differential pair at a second input of the differential amplifier to provide a clock signal for memory operations. Thus, the termination circuit may reduce an amount by which noise associated with the unused signal line affects the differential amplifier when the memory device operates in SE mode.