- 专利标题： Substituted amines as disrupters of ABETA42 oligomer formation
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申请号： US16836835申请日： 2020-03-31
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公开(公告)号： US11827582B2公开(公告)日： 2023-11-28
- 发明人: Ambuj K. Singh , Christian A. Lang
- 申请人： ACELOT, INC.
- 申请人地址： US CA Palo Alto
- 专利权人： ACELOT, INC.
- 当前专利权人： ACELOT, INC.
- 当前专利权人地址： US CA Palo Alto
- 代理机构： Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C.
- 分案原申请号： US16350344 2018.11.05
- 主分类号： C07C211/23
- IPC分类号： C07C211/23 ; C07C233/43 ; C07C271/18 ; A61K31/135 ; A61K31/137 ; C07C223/02 ; C07C211/28 ; C07C211/29 ; A61K31/131 ; C07C211/27 ; C07C217/60 ; C07D207/06 ; C07D295/135 ; C07D295/15 ; C07D319/18 ; C07D413/06
摘要：
The present disclosure provides small molecule drugs and pharmaceutical compositions for the treatment and prevention of diseases related to the formation of Aβ42 oligomers in a subject. It further provides a method of reducing formation of or disrupting Aβ42 oligomers in a subject, the method comprising the step of administering to the subject in need thereof a therapeutically effective amount of a pharmaceutical composition. One such compound is a compound of formula 120:
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