- 专利标题： Activator of TREK (TWIK RElated K
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申请号： US17328814申请日： 2021-05-24
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公开(公告)号： US11851428B2公开(公告)日： 2023-12-26
- 发明人: Craig W. Lindsley , Joshua M. Wieting , Kevin M. Mcgowan , Jerod S. Denton , Kentaro Yashiro , Haruto Kurata , Yoko Sekioka , Takahiro Mori , Yuzo Iwaki
- 申请人： ONO PHARMACEUTICAL CO., LTD. , VANDERBILT UNIVERSITY
- 申请人地址： JP TN Osaka
- 专利权人： ONO PHARMACEUTICAL CO., LTD.,VANDERBILT UNIVERSITY
- 当前专利权人： ONO PHARMACEUTICAL CO., LTD.,VANDERBILT UNIVERSITY
- 当前专利权人地址： JP Osaka; US TN Nashville
- 代理机构： Foley & Lardner LLP
- 分案原申请号： US16470196
- 主分类号： C07D213/36
- IPC分类号： C07D213/36 ; C07D231/12 ; C07D249/08 ; C07D401/04 ; A61K31/454 ; C07D471/04 ; C07C255/57 ; C07C317/28 ; C07D209/30 ; C07D213/89 ; C07D231/56 ; C07D235/16 ; C07D237/24 ; C07D239/47 ; C07D249/18 ; C07D257/04 ; C07D265/36 ; C07D271/10 ; C07D285/14 ; C07D295/04 ; C07D513/04
摘要：
Disclosed is a compound of formula (I):
wherein all symbols are defined in the description. Also disclosed are pharmaceutical compositions comprising the compounds, methods of making the compounds, kits comprising the compounds, and methods of using the compounds, compositions and kits for treatment of disorders associated with TREK-1, TREK-2 or both TREK-1 and TREK-2 dysfunction in a mammal.
wherein all symbols are defined in the description. Also disclosed are pharmaceutical compositions comprising the compounds, methods of making the compounds, kits comprising the compounds, and methods of using the compounds, compositions and kits for treatment of disorders associated with TREK-1, TREK-2 or both TREK-1 and TREK-2 dysfunction in a mammal.
公开/授权文献
- US20210347773A1 ACTIVATOR OF TREK (TWIK RELATED K+ CHANNELS) CHANNELS 公开/授权日：2021-11-11
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