Invention Grant
![Solid forms of N-(4-fluoro-3-(6-(3-methylpyridin-2-yl)-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)phenyl)-2,4-dimethyloxazole-5-carboxamide](/docs/US/2024-02-06/US11891401B2/abs.jpg.600x600.jpg)
- Patent Title: Solid forms of N-(4-fluoro-3-(6-(3-methylpyridin-2-yl)-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)phenyl)-2,4-dimethyloxazole-5-carboxamide
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Application No.: US17281528Application Date: 2019-10-08
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Publication No.: US11891401B2Publication Date: 2024-02-06
- Inventor: Yudong Cao , Siyi Jiang , Hongyong Kim , Andreas Kordikowski , Irene Xia , Bo Yu , Jing Zhang , Yi Zhao
- Applicant: NOVARTIS AG
- Applicant Address: CH Basel
- Assignee: NOVARTIS AG
- Current Assignee: NOVARTIS AG
- Current Assignee Address: CH Basel
- Agent Emily T. Wu
- Priority: WO TCN2018109415 2018.10.09
- International Application: PCT/IB2019/058535 2019.10.08
- International Announcement: WO2020/075046A 2020.04.16
- Date entered country: 2021-03-30
- Main IPC: C07D487/04
- IPC: C07D487/04 ; A61K31/519 ; A61K45/06 ; C07C57/15 ; A61P33/02
![Solid forms of N-(4-fluoro-3-(6-(3-methylpyridin-2-yl)-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)phenyl)-2,4-dimethyloxazole-5-carboxamide](/abs-image/US/2024/02/06/US11891401B2/abs.jpg.150x150.jpg)
Abstract:
The application relates to N-(4-fluoro-3-(6-(3-methylpyridin-2-yl)-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)phenyl)-2,4-dimethyloxazole-5-carboxamide (Compound I) fumaric acid co-crystals and X-ray amorphous complexes of Compound (I) and fumaric acid. The application also provides methods of making the same; pharmaceutical compositions comprising them; and their use in treating, preventing, inhibiting, ameliorating, or eradicating the pathology and/or symptomology of a disease caused by a kinetoplastid parasite, such as leishmaniasis, human African trypanosomiasis and Chagas disease.
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