公开(公告)号：US11891401B2

公开(公告)日：2024-02-06

申请号：US17281528

申请日：2019-10-08

Applicant: NOVARTIS AG

Inventor： Yudong Cao ,  Siyi Jiang ,  Hongyong Kim ,  Andreas Kordikowski ,  Irene Xia ,  Bo Yu ,  Jing Zhang ,  Yi Zhao

IPC: C07D487/04 ,  A61K31/519 ,  A61K45/06 ,  C07C57/15 ,  A61P33/02

CPC classification number: C07D487/04 ,  A61K31/519 ,  A61K45/06 ,  A61P33/02 ,  C07C57/15 ,  C07B2200/13

Abstract: The application relates to N-(4-fluoro-3-(6-(3-methylpyridin-2-yl)-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)phenyl)-2,4-dimethyloxazole-5-carboxamide (Compound I) fumaric acid co-crystals and X-ray amorphous complexes of Compound (I) and fumaric acid. The application also provides methods of making the same; pharmaceutical compositions comprising them; and their use in treating, preventing, inhibiting, ameliorating, or eradicating the pathology and/or symptomology of a disease caused by a kinetoplastid parasite, such as leishmaniasis, human African trypanosomiasis and Chagas disease.

公开(公告)号：US10071973B2

公开(公告)日：2018-09-11

申请号：US15620373

申请日：2017-06-12

Applicant: Novartis AG

Inventor： Jiping Fu ,  Siyi Jiang ,  Andreas Kordikowski ,  Zachary Kevin Sweeney

IPC: C07D261/08 ,  A61K31/7048 ,  A61K38/14 ,  A61K38/12 ,  A61K31/431 ,  A61K31/65 ,  A61K31/7036 ,  A61K31/496 ,  A61K31/5383 ,  A61K31/42 ,  A61K31/43 ,  A61K31/546

CPC classification number: C07D261/08 ,  A61K31/42 ,  A61K31/43 ,  A61K31/431 ,  A61K31/496 ,  A61K31/5383 ,  A61K31/546 ,  A61K31/65 ,  A61K31/7036 ,  A61K31/7048 ,  A61K38/12 ,  A61K38/14 ,  C07B2200/13

Abstract: This invention pertains to a crystalline compound of Formula (A) as described herein and compositions containing this crystalline compound, as well as methods of using the compound or pharmaceutical compositions comprising it to treat bacterial infections. The compound and compositions are especially useful to treat Gram negative bacterial infections, including multi-drug resistant strains.