公开(公告)号：US11891401B2

公开(公告)日：2024-02-06

申请号：US17281528

申请日：2019-10-08

Applicant: NOVARTIS AG

Inventor： Yudong Cao ,  Siyi Jiang ,  Hongyong Kim ,  Andreas Kordikowski ,  Irene Xia ,  Bo Yu ,  Jing Zhang ,  Yi Zhao

IPC: C07D487/04 ,  A61K31/519 ,  A61K45/06 ,  C07C57/15 ,  A61P33/02

CPC classification number: C07D487/04 ,  A61K31/519 ,  A61K45/06 ,  A61P33/02 ,  C07C57/15 ,  C07B2200/13

Abstract: The application relates to N-(4-fluoro-3-(6-(3-methylpyridin-2-yl)-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)phenyl)-2,4-dimethyloxazole-5-carboxamide (Compound I) fumaric acid co-crystals and X-ray amorphous complexes of Compound (I) and fumaric acid. The application also provides methods of making the same; pharmaceutical compositions comprising them; and their use in treating, preventing, inhibiting, ameliorating, or eradicating the pathology and/or symptomology of a disease caused by a kinetoplastid parasite, such as leishmaniasis, human African trypanosomiasis and Chagas disease.