- 专利标题： Glycan-masked engineered outer domains of HIV-1 gp120 and their use
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申请号： US17587817申请日： 2022-01-28
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公开(公告)号： US12053520B2公开(公告)日： 2024-08-06
- 发明人: Xuejun Chen , Jeffrey Boyington , Hongying Duan Holdsworth , Cheng Cheng , John R. Mascola
- 申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services
- 申请人地址： US MD Bethesda
- 专利权人： The United States of America, as represented by the Secretary, Department of Health and Human Services
- 当前专利权人： The United States of America, as represented by the Secretary, Department of Health and Human Services
- 当前专利权人地址： US MD Bethesda
- 代理机构： Klarquist Sparkman, LLP
- 主分类号： A61K39/21
- IPC分类号： A61K39/21 ; C07K14/005 ; C07K14/16 ; C12N7/00 ; A61K39/00
摘要：
Embodiments of immunogens based on the outer domain of HIV-1 gp120 and methods of their use and production are disclosed. Nucleic acid molecules encoding the immunogens are also provided. In several embodiments, the immunogens can be used to prime an immune response to gp120 in a subject, for example, to treat or prevent an HIV-1 infection in the subject.
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