专利检索 ap:("The United States of America, as represented by the Secretary, Department of Health AND Human Services") AND inv:"Xuejun Chen" 第 1 页

1.

发明授权
Glycan-masked engineered outer domains of HIV-1 gp120 and their use 有权

公开(公告)号：US11235056B2

公开(公告)日：2022-02-01

申请号：US16496912

申请日：2018-03-26

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services

发明人： Xuejun Chen , Jeffrey Boyington , Hongying Duan Holdsworth , Cheng Cheng , John R. Mascola

IPC分类号： A61K39/21 , C07K14/005 , C12N7/00 , C07K14/16 , A61K39/00

摘要： Embodiments of immunogens based on the outer domain of HIV-1 gp120 and methods of their use and production are disclosed. Nucleic acid molecules encoding the immunogens are also provided. In several embodiments, the immunogens can be used to prime an immune response to gp120 in a subject, for example, to treat or prevent an HIV-1 infection in the subject.

2.

发明授权
Glycan-masked engineered outer domains of HIV-1 gp120 and their use 有权

公开(公告)号：US12053520B2

公开(公告)日：2024-08-06

申请号：US17587817

申请日：2022-01-28

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services

发明人： Xuejun Chen , Jeffrey Boyington , Hongying Duan Holdsworth , Cheng Cheng , John R. Mascola

IPC分类号： A61K39/21 , C07K14/005 , C07K14/16 , C12N7/00 , A61K39/00

CPC分类号： A61K39/21 , C07K14/005 , C07K14/162 , C12N7/00 , C12Y205/01078 , A61K2039/5258 , A61K2039/55555 , C07K2319/00 , C12N2740/16023 , C12N2740/16043 , C12N2740/16111 , C12N2740/16122 , C12N2740/16134 , C12N2740/16171

摘要： Embodiments of immunogens based on the outer domain of HIV-1 gp120 and methods of their use and production are disclosed. Nucleic acid molecules encoding the immunogens are also provided. In several embodiments, the immunogens can be used to prime an immune response to gp120 in a subject, for example, to treat or prevent an HIV-1 infection in the subject.