Invention Grant
- Patent Title: High-yielding continuous flow synthesis of antimalarial drug hydroxychloroquine
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Application No.: US16975434Application Date: 2019-02-25
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Publication No.: US12071410B2Publication Date: 2024-08-27
- Inventor: Frank B. Gupton , Saeed Ahmad , Hari P. R. Gunuru , Nakul S. Telang
- Applicant: VIRGINIA COMMONWEALTH UNIVERSITY
- Applicant Address: US VA Richmond
- Assignee: Virginia Commonwealth University
- Current Assignee: Virginia Commonwealth University
- Current Assignee Address: US VA Richmond
- Agency: WC&F IP
- International Application: PCT/US2019/019336 2019.02.25
- International Announcement: WO2019/165337A 2019.08.29
- Date entered country: 2020-08-25
- Main IPC: C07D215/46
- IPC: C07D215/46 ; B01J8/04 ; B01J19/00 ; B01J19/18 ; B01J19/24
Abstract:
Cost effective, semi-continuous flow methods and systems for synthesizing the antimalarial drug hydroxychloroquine (HCQ) in high yield are provided. The synthesis method that uses simple, inexpensive reagents to obtain the crucial intermediate 5-(ethyl(2-hydroxyethyl)-amino)pentan-2-one, vertical-integration of the starting material 5-iodopentan-2-one and the integration of continuous stirred tank reactors.
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