公开(公告)号：US12071410B2

公开(公告)日：2024-08-27

申请号：US16975434

申请日：2019-02-25

Applicant: VIRGINIA COMMONWEALTH UNIVERSITY

Inventor： Frank B. Gupton ,  Saeed Ahmad ,  Hari P. R. Gunuru ,  Nakul S. Telang

IPC: C07D215/46 ,  B01J8/04 ,  B01J19/00 ,  B01J19/18 ,  B01J19/24

CPC classification number: C07D215/46 ,  B01J8/0492 ,  B01J19/0013 ,  B01J19/0066 ,  B01J19/1862 ,  B01J19/245 ,  B01J2219/00033 ,  B01J2219/0004

Abstract: Cost effective, semi-continuous flow methods and systems for synthesizing the antimalarial drug hydroxychloroquine (HCQ) in high yield are provided. The synthesis method that uses simple, inexpensive reagents to obtain the crucial intermediate 5-(ethyl(2-hydroxyethyl)-amino)pentan-2-one, vertical-integration of the starting material 5-iodopentan-2-one and the integration of continuous stirred tank reactors.