公开(公告)号：US12071410B2

公开(公告)日：2024-08-27

申请号：US16975434

申请日：2019-02-25

Applicant: VIRGINIA COMMONWEALTH UNIVERSITY

Inventor： Frank B. Gupton ,  Saeed Ahmad ,  Hari P. R. Gunuru ,  Nakul S. Telang

IPC: C07D215/46 ,  B01J8/04 ,  B01J19/00 ,  B01J19/18 ,  B01J19/24

CPC classification number: C07D215/46 ,  B01J8/0492 ,  B01J19/0013 ,  B01J19/0066 ,  B01J19/1862 ,  B01J19/245 ,  B01J2219/00033 ,  B01J2219/0004

Abstract: Cost effective, semi-continuous flow methods and systems for synthesizing the antimalarial drug hydroxychloroquine (HCQ) in high yield are provided. The synthesis method that uses simple, inexpensive reagents to obtain the crucial intermediate 5-(ethyl(2-hydroxyethyl)-amino)pentan-2-one, vertical-integration of the starting material 5-iodopentan-2-one and the integration of continuous stirred tank reactors.

公开(公告)号：US10000453B2

公开(公告)日：2018-06-19

申请号：US15532828

申请日：2015-12-03

Applicant: VIRGINIA COMMONWEALTH UNIVERSITY

Inventor： Keith C. Ellis ,  Frank B. Gupton

IPC: C07D211/84 ,  C07D221/10 ,  B01J23/44 ,  B01J21/18 ,  C07D215/06 ,  C07D213/30 ,  C07D213/26 ,  C07C249/04

CPC classification number: C07D221/10 ,  B01J21/185 ,  B01J23/44 ,  B01J37/0036 ,  B01J37/04 ,  C07C249/04 ,  C07C2602/10 ,  C07D213/16 ,  C07D213/26 ,  C07D213/30 ,  C07D213/61 ,  C07D215/06 ,  C07D215/14

Abstract: Chelation directed C—H activation reactions that are catalyzed by Pd(11) on Multi-Walled Carbon Nanotubes (MWCNT), Single-Walled Carbon Nanotubes (SWCNT), or graphene are provided. The reactions are used to directly and regioselectively or regiospecifically functionalize specific C—H bonds, e.g. to build complexity into small molecules. Features and advantages of the present invention will be set forth in the description of invention that follows, and in part will be apparent from the description or may be learned by practice of the invention. The invention will be realized and attained by the compositions and methods particularly pointed out in the written description and claims hereof.

公开(公告)号：US11059788B2

公开(公告)日：2021-07-13

申请号：US16621992

申请日：2018-06-12

Applicant: VIRGINIA COMMONWEALTH UNIVERSITY

Inventor： Frank B. Gupton ,  Perrer N. Tosso

IPC: C07D403/04 ,  C07D215/56 ,  C07C227/16 ,  C07C229/34

Abstract: Methods of synthesizing fluoroquinolones such as ciprofloxacin are provided. The methods utilize affordable materials, reduce the number of synthesis steps and provide high yields.