The present disclosure relates generally to systems, devices, and methods for endoscopic suture termination. In some embodiments, a suture device may include an elongate member having a working channel and a suture channel, the elongate member having a proximal end and a distal end. The suture device may further include a suture extending through the suture channel, and a plurality of anchor components coupled to the suture, wherein the suture and the plurality of anchor components are deployable from the elongate member for engagement with a target tissue.