Methods and systems are provided for responding to an attacker including a shooter who opens fire at a site where people are gathered, including identifying, neutralizing, and restraining the attacker. A system may include a central control unit configured to perform a series of steps including: receiving an image including the origin of the gunfire and responsively acquiring identifying features of a shooter associated with the gunfire; subsequently tracking a current location of the shooter according to the identifying features; releasing an autonomous, unmanned aerial vehicle (UAV) to engage the shooter; guiding the flight of the UAV towards the current location of the shooter; and neutralizing the shooter by operating a shooter incapacitating mechanism of the UAV.