Invention Grant
- Patent Title: Enhancing formation of milk oligosaccharides (HMOs) by modifying lactose import in the cell
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Application No.: US18561258Application Date: 2022-05-17
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Publication No.: US12286658B2Publication Date: 2025-04-29
- Inventor: Manos Papadakis
- Applicant: DSM IP Assets B.V.
- Applicant Address: DK Heerlen
- Assignee: DSM IP Assets B.V.
- Current Assignee: DSM IP Assets B.V.
- Current Assignee Address: DK Heerlen
- Agency: Neal, Gerber & Eisenberg LLP
- Priority: DKPA202170249 20210517
- International Application: PCT/EP2022/063311 WO 20220517
- International Announcement: WO2022/243308 WO 20221124
- Main IPC: C12P19/18
- IPC: C12P19/18 ; C12N9/10 ; C12N15/52 ; C12P19/00
Abstract:
This invention relates to a method of producing one or more human milk oligosaccharides (HMOs), in particular LNT and/or LNnT, in a genetically engineered cell comprising an enhanced oligosaccharide transport capability. The genetically modified cell comprises a series of genetic modification which enable the production of one or more HMO(s), and a series of genetic modification that enhances the transport of lactose and produced HMO(s).
Public/Granted literature
- US20240279697A1 ENHANCING FORMATION OF HUMAN MILK OLIGOSACCHARIDES (HMOS) BY MODIFYING LACTOSE IMPORT IN THE CELL Public/Granted day:2024-08-22
Information query
