发明申请
- 专利标题: Novel compounds and a novel process for their preparation
- 专利标题(中): 新型化合物及其制备方法
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申请号: US10855783申请日: 2004-05-28
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公开(公告)号: US20050014721A1公开(公告)日: 2005-01-20
- 发明人: Keith Fagnou , Mark Lautens
- 申请人: Keith Fagnou , Mark Lautens
- 优先权: SE9903930-7 19991029
- 主分类号: C07D295/08
- IPC分类号: C07D295/08 ; A61K31/055 ; A61K31/085 ; A61K31/09 ; A61K31/136 ; A61K31/18 ; A61K31/222 ; A61K31/225 ; A61K31/235 ; A61K31/27 ; A61K31/277 ; A61K31/36 ; A61K31/40 ; A61K31/4035 ; A61K31/404 ; A61K31/4453 ; A61K31/47 ; A61K31/472 ; A61K31/4725 ; A61P25/16 ; A61P29/00 ; A61P31/04 ; A61P31/12 ; A61P31/18 ; A61P35/00 ; A61P37/02 ; A61P43/00 ; C07B61/00 ; C07C27/00 ; C07C41/01 ; C07C41/03 ; C07C43/196 ; C07C43/23 ; C07C43/253 ; C07C43/295 ; C07C45/71 ; C07C49/84 ; C07C67/24 ; C07C69/013 ; C07C69/16 ; C07C69/732 ; C07C205/38 ; C07C215/44 ; C07C215/86 ; C07C217/52 ; C07C219/00 ; C07C255/54 ; C07C271/24 ; C07C271/28 ; C07C311/20 ; C07C311/21 ; C07D209/08 ; C07D209/48 ; C07D215/06 ; C07D217/04 ; C07D295/096 ; C07D295/12 ; C07D295/135 ; C07D317/70 ; C07D493/08 ; C07D493/18 ; C07F7/08 ; C07F7/18 ; A61K31/695 ; A61K31/54 ; A61K31/537 ; A61K31/495 ; A61K31/135
摘要:
The present invention is directed to a procedure for making an enantiomerically enriched compound containing a hydronaphthalene ring structure. The process involves reacting oxabenzonorbornadienes with nucleophiles using rhodium as a catalyst and in the presence of a phosphine ligand. The compounds synthesized may be used in pharmaceutical preparations for the treatment of a variety of diseases and conditions.
公开/授权文献
- US07420003B2 Compounds and a novel process for their preparation 公开/授权日:2008-09-02