发明申请
- 专利标题： Pharmaceutical compositions with improved dissolution
- 专利标题（中）： 具有改善溶出度的药物组合物
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申请号： US10601092申请日： 2003-06-20
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公开(公告)号： US20050025791A1公开(公告)日： 2005-02-03
- 发明人: Julius Remenar , Matthew Peterson , Orn Almarsson , Hector Guzman , Hongming Chen , Mark Tawa , Mark Oliveira
- 申请人： Julius Remenar , Matthew Peterson , Orn Almarsson , Hector Guzman , Hongming Chen , Mark Tawa , Mark Oliveira
- 主分类号： A61K9/14
- IPC分类号： A61K9/14 ; A61K9/16 ; A61K9/64 ; A61K31/18 ; A61K31/365 ; A61K31/415 ; A61K31/635 ; A61K47/10 ; A61K47/32 ; C07B63/00 ; G01N21/27 ; G01N25/08 ; G01N25/12 ; G01N33/15 ; A61K9/00
摘要：
The invention relates to methods of screening mixtures containing a pharmaceutical compound and an excipient to identify properties of the pharmaceutical compound/excipient combination that retard solid-state nucleation. The invention further relates to increasing the solubility, dissolution and bioavailability of a drug with low solubility in gastric fluids conditions by combining the drug with a recrystallization/precipitation retardant and an optional enhancer.