Invention Application
US20050032109A1 Mutants of the factor VII-activating protease and detection methods using specific antibodies
有权
因子VII活化蛋白酶的突变体和使用特异性抗体的检测方法
- Patent Title: Mutants of the factor VII-activating protease and detection methods using specific antibodies
- Patent Title (中): 因子VII活化蛋白酶的突变体和使用特异性抗体的检测方法
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Application No.: US10930754Application Date: 2004-09-01
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Publication No.: US20050032109A1Publication Date: 2005-02-10
- Inventor: Juergen Roemisch , Hans-Arnold Stoehr , Annette Feussner , Wiegand Lang , Thomas Weimer , Margret Becker , Claudia Nerlich , Gudrun Muth-Naumann , Bernd Knoblauch
- Applicant: Juergen Roemisch , Hans-Arnold Stoehr , Annette Feussner , Wiegand Lang , Thomas Weimer , Margret Becker , Claudia Nerlich , Gudrun Muth-Naumann , Bernd Knoblauch
- Assignee: Aventis Behring GmbH
- Current Assignee: Aventis Behring GmbH
- Priority: DE10036641.4 20000726; DE10050040.4 20001010; DE10052319.6 20001021; DE10118706.8 20010412
- Main IPC: G01N33/53
- IPC: G01N33/53 ; C07K16/40 ; C12N9/50 ; C12N9/64 ; C12N15/09 ; C12N15/57 ; C12P21/08 ; C12Q1/56 ; C12Q1/68 ; G01N33/533 ; G01N33/534 ; G01N33/535 ; C07H21/04 ; C07K14/755 ; C12P21/04
Abstract:
Mutants of the DNA sequence coding for the protease (FSAP) which activates blood clotting factor VII and single-chain plasminogen activators, the mutant comprising a G/C base exchange at nucleotide position 1177 and/or a G/A base exchange at nucleotide position 1601, is described. The corresponding protease has a Glu/Gln exchange at amino acid position 393 and/or a Gly/Glu exchange at amino acid position 534. Furthermore, diagnostic methods which are used for detecting FSAP in body fluids or tissue cells and also for identifying patients with genetic heterozygous or homozygous FSAP expression are described. In addition, antibodies against FSAP and its mutants are disclosed and diagnostic methods which can be used to detect antibodies against FSAP and its mutants are specified.
Public/Granted literature
- US07442514B2 Mutants of the factor VII-activating protease and detection methods using specific antibodies Public/Granted day:2008-10-28
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