发明申请
- 专利标题： Method of immobilizing membrane-associated molecules
- 专利标题（中）： 固定膜相关分子的方法
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申请号： US10815727申请日： 2004-04-02
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公开(公告)号： US20050032246A1公开(公告)日： 2005-02-10
- 发明人: John Brennan , Michael Brook , Travis Besanger
- 申请人： John Brennan , Michael Brook , Travis Besanger
- 申请人地址： CA Hamilton
- 专利权人： McMaster University
- 当前专利权人： McMaster University
- 当前专利权人地址： CA Hamilton
- 主分类号： G01N33/543
- IPC分类号： G01N33/543 ; G01N33/552 ; G01N33/68 ; A61L2/00 ; C12P21/06
摘要：
The present invention relates to methods of immobilizing membrane-associated molecules within a sol-gel matrix. The membrane-associated molecule is embedded in the bilayer of a liposome. The molecule-liposome assembly remains functionally intact when it is immobilized within a protein and membrane-compatible sol-gel derived from polyol silane precursors or sodium silicate. The activity and stability of the entrapped membrane-associated molecule was significantly improved in macroporous silica.
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