发明申请
- 专利标题： Keratinocyte growth factor-2
- 专利标题（中）： 角质形成细胞生长因子-2
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申请号： US10901210申请日： 2004-07-29
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公开(公告)号： US20050037966A1公开(公告)日： 2005-02-17
- 发明人: Steven Ruben , Pablo Jimenez , Roxanne Duan , Mark Rampy , Donna Mendrick , Jun Zhang , Jian Ni , Paul Moore , Timothy Coleman , Joachim Gruber , Patrick Dillon , Reiner Gentz
- 申请人： Steven Ruben , Pablo Jimenez , Roxanne Duan , Mark Rampy , Donna Mendrick , Jun Zhang , Jian Ni , Paul Moore , Timothy Coleman , Joachim Gruber , Patrick Dillon , Reiner Gentz
- 申请人地址： US MD Rockville
- 专利权人： Human Genome Sciences, Inc.
- 当前专利权人： Human Genome Sciences, Inc.
- 当前专利权人地址： US MD Rockville
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; A61K48/00 ; C07K14/50 ; C12N5/08 ; A61K38/18 ; C07K14/475
摘要：
This invention relates to newly identified polynucleotides, polypeptides encoded by such polynucleotides, the use of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides. More particularly, the polypeptide of the present invention is a Keratinocyte Growth Factor, sometimes hereinafter referred to as “KGF-2” also formerly known as Fibroblast Growth Factor 12 (FGF-12). This invention further relates to the therapeutic use of KGF-2 to promote or accelerate wound healing. This invention also relates to novel mutant forms of KGF-2 that show enhanced activity, increased stability, higher yield or better solubility.
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