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公开(公告)号：US20070275895A1
公开(公告)日：2007-11-29
申请号：US11738846
申请日：2007-04-23
Applicant: D. Duan , Steven Ruben
Inventor： D. Duan , Steven Ruben
IPC: C07K14/435 , A61K38/17 , A61P15/00 , A61P19/00 , C12N15/63 , C12P21/00 , C12N5/10 , C07K16/18 , A61P35/00 , C07H21/04
CPC classification number: C07K14/4703 , A61K38/00 , A61K39/00 , A61K48/00 , C07K2319/00 , C12N2799/021 , C12N2799/026
Abstract: The present invention relates to a novel follistatin-3 protein which is a member of the family of inhibin-related proteins. In particular, isolated nucleic acid molecules are provided encoding the human follistatin-3 protein. Follistatin-3 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of follistatin-3 activity. Also provided are diagnostic methods for detecting reproductive system-related disorders and disorders of the regulation of cell growth and differentiation and therapeutic methods for treating reproductive system-related disorders and disorders of the regulation of cell growth and differentiation.
Abstract translation: 本发明涉及作为抑制素相关蛋白家族成员的新型卵泡抑素-3蛋白。 特别地，提供编码人卵泡抑素-3蛋白的分离的核酸分子。 还提供了Follistatin-3多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明还涉及用于鉴定卵泡抑素-3活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测生殖系统相关疾病和细胞生长和分化调节紊乱的诊断方法以及用于治疗生殖系统相关疾病和调节细胞生长和分化的紊乱的治疗方法。
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公开(公告)号：US20070048818A1
公开(公告)日：2007-03-01
申请号：US10868184
申请日：2004-06-16
Applicant: Craig Rosen , Steven Ruben , George Komatsoulis
Inventor： Craig Rosen , Steven Ruben , George Komatsoulis
CPC classification number: C07K14/47
Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
Abstract translation: 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。
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公开(公告)号：US20070020277A1
公开(公告)日：2007-01-25
申请号：US11532050
申请日：2006-09-14
Applicant: Henrik Olsen , Steven Ruben
Inventor： Henrik Olsen , Steven Ruben
CPC classification number: C07K14/47 , A61K38/00 , A61K48/00 , C12N2799/026
Abstract: The present invention relates to a novel protein, the Human Oncogene Induced Secreted Protein I (“HOIPS I”) protein. In particular, isolated nucleic acid molecules are provided encoding the human HOIPS I protein. HOIPS I polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. Antibodies to human HOIPS I are also provided, as are diagnostic methods for detecting abnormal cell proliferation and differentiation disorders and therapeutic methods for treating the same.
Abstract translation: 本发明涉及一种新的蛋白质，即人癌基因诱导的分泌蛋白I（“HOIPS I”）蛋白质。 特别地，提供编码人HOIPS I蛋白的分离的核酸分子。 还提供HOIPS I多肽，载体，宿主细胞和用于制备其的重组方法。 还提供了人HOIPS I的抗体，以及用于检测异常细胞增殖和分化障碍的诊断方法以及用于治疗它们的治疗方法。
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公开(公告)号：US20070015162A1
公开(公告)日：2007-01-18
申请号：US10670185
申请日：2003-09-25
Applicant: Craig Rosen , Steven Ruben
Inventor： Craig Rosen , Steven Ruben
CPC classification number: C12Q1/6883 , C07K14/47 , C12Q2600/156 , C12Q2600/158 , G01N33/6893 , G01N2500/04 , G01N2800/24
Abstract: The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding said polypeptides, useful for diagnosing and treating allergic and asthmatic disorders. Antibodies that bind these polypeptides are also encompassed by the present invention. Also encompassed by the invention are vectors, host cells, and recombinant and synthetic methods for producing said polynucleotides, polypeptides, and/or antibodies. The invention further encompasses screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further encompasses methods and compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.
Abstract translation: 本发明涉及人分泌多肽，以及编码所述多肽的分离的核酸分子，其可用于诊断和治疗过敏性和哮喘性疾病。 结合这些多肽的抗体也包括在本发明中。 本发明还包括载体，宿主细胞以及用于产生所述多核苷酸，多肽和/或抗体的重组和合成方法。 本发明还包括用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。 本发明还包括用于抑制或增强本发明多肽的产生和功能的方法和组合物。
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公开(公告)号：US20060246483A1
公开(公告)日：2006-11-02
申请号：US11366486
申请日：2006-03-03
Applicant: Craig Rosen , Steven Ruben
Inventor： Craig Rosen , Steven Ruben
CPC classification number: C07K14/47
Abstract: The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding said polypeptides, useful for diagnosing and treating cardiovascular diseases, disorders, and/or conditions related thereto. Antibodies that bind these polypeptides are also encompassed by the present invention. Also encompassed by the invention are vectors, host cells, and recombinant and synthetic methods for producing said polynucleotides, polypeptides, and/or antibodies. The invention further encompasses screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further encompasses methods and compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.
Abstract translation: 本发明涉及人分泌的多肽，以及编码所述多肽的分离的核酸分子，其可用于诊断和治疗与之有关的心血管疾病，病症和/或病症。 结合这些多肽的抗体也包括在本发明中。 本发明还包括载体，宿主细胞，以及用于产生所述多核苷酸，多肽和/或抗体的重组和合成方法。 本发明还包括用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。 本发明还包括用于抑制或增强本发明多肽的产生和功能的方法和组合物。
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Patent Agency Ranking
公开(公告)号：US20060166327A1
公开(公告)日：2006-07-27
申请号：US11389101
申请日：2006-03-27
Applicant: Daniel Soppet , Yi Li , Craig Rosen , Steven Ruben
Inventor： Daniel Soppet , Yi Li , Craig Rosen , Steven Ruben
IPC: C07H21/04 , C12P21/06 , C07K14/705
CPC classification number: C07K14/7158 , A61K38/00 , C07K14/723
Abstract: Human G-protein coupled receptor polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed were methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the agonists and antagonists therapeutically to treat conditions related to the underexpression and overexpression of the G-protein coupled receptor polypeptides, respectively. Also disclosed are diagnostic methods for detecting a mutation in the G-protein coupled receptor nucleic acid sequences and an altered level of the soluble form of the receptors.
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公开(公告)号：US20060099575A9
公开(公告)日：2006-05-11
申请号：US09949925
申请日：2001-09-12
Applicant: Steven Ruben , Ann Ferrie , Craig Rosen , Kimberly Florence , Kenneth Carter , Daniel Soppet , Guo-Liang Yu , Charles Florence , Paul Young , Jian Ni , Gregory Endress , Ping Feng , Fouad Janat , Charles Birse
Inventor： Steven Ruben , Ann Ferrie , Craig Rosen , Kimberly Florence , Kenneth Carter , Daniel Soppet , Guo-Liang Yu , Charles Florence , Paul Young , Jian Ni , Gregory Endress , Ping Feng , Fouad Janat , Charles Birse
CPC classification number: C07K14/47
Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
Abstract translation: 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。
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公开(公告)号：US20060062789A1
公开(公告)日：2006-03-23
申请号：US11266444
申请日：2005-11-04
Applicant: Steven Ruben , Steven Barash , Gil Choi , Tristan Vaughan , David Hilbert
Inventor： Steven Ruben , Steven Barash , Gil Choi , Tristan Vaughan , David Hilbert
IPC: C07K16/24 , A61K39/395 , G01N33/53
CPC classification number: C07K14/70575 , A61K47/6849 , A61K49/0004 , A61K2039/505 , C07K14/52 , C07K16/2875 , C07K2317/21 , C07K2317/622 , G01N33/564
Abstract: The present invention relates to antibodies and related molecules that immunospecifically bind to B Lymphocyte Stimulator. The present invention also relates to methods and compositions for detecting or diagnosing a disease or disorder associated with aberrant B Lymphocyte Stimulator expression or inappropriate function of B Lymphocyte Stimulator comprising antibodies or fragments or variants thereof or related molecules that immunospecifically bind to B Lymphocyte Stimulator. The present invention further relates to methods and compositions for preventing, treating or ameliorating a disease or disorder associated with aberrant B Lymphocyte Stimulator expression or inappropriate B Lymphocyte Stimulator function comprising administering to an animal an effective amount of one or more antibodies or fragments or variants thereof or related molecules that immunospecifically bind to B Lymphocyte Stimulator.
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公开(公告)号：US20060003378A1
公开(公告)日：2006-01-05
申请号：US11214796
申请日：2005-08-31
Applicant: Paul Young , Steven Ruben , Craig Rosen , Henrik Olsen
Inventor： Paul Young , Steven Ruben , Craig Rosen , Henrik Olsen
IPC: C12Q1/68 , C07H21/04 , C12P21/06 , C07K14/705 , C07K16/28
Abstract: The present invention related to three novel recognition protein expressed by keratinocytes, wound-healing tissues and chondrosarcoma tissue. More specifically, isolated nucleic acid molecules are provided encoding human peptidoglycan recognition protein-related proteins, referred to herein as PGRP-K (Keratinocytes), PGRP-W (Wound-healing), and PGRP-C (Chondrosarcoma) of FIGS. 1A-B, FIGS. 2A-C, and FIG. 3, respectively, each having homology to both human peptidoglycan recognition protein (PGRP) as well as murine Tag-7. PGRP-K, PGRP-W, and PGRP-C polypeptides are also provided. Further provided are vectors, host cells and recombinant methods for producing the same. The invention also relates to both the inhibition and enhancement of activities of PGRP-K, PGRP-W, and PGRP-C polypeptides and diagnostic methods for detecting PGRP-K, PGRP-W, and PGRP-C gene expression.
Abstract translation: 本发明涉及由角质形成细胞，伤口愈合组织和软骨肉瘤组织表达的三种新型识别蛋白。 更具体地，提供分离的核酸分子，其编码人胶原聚糖识别蛋白相关蛋白（本文称为PGRP-K（角质形成细胞），PGRP-W（伤口愈合）和PGRP-C（软骨肉瘤））。 图1A-B， 图2A-C， 3，分别与人肽聚糖识别蛋白（PGRP）以及鼠Tag-7都具有同源性。 还提供了PGRP-K，PGRP-W和PGRP-C多肽。 进一步提供载体，宿主细胞和用于制备其的重组方法。 本发明还涉及PGRP-K，PGRP-W和PGRP-C多肽的活性的抑制和增强以及用于检测PGRP-K，PGRP-W和PGRP-C基因表达的诊断方法。
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公开(公告)号：US20050255532A1
公开(公告)日：2005-11-17
申请号：US11054515
申请日：2005-02-10
Applicant: Steven Ruben , Steven Barash , Gil Choi , Tristan Vaughan , David Hilbert
Inventor： Steven Ruben , Steven Barash , Gil Choi , Tristan Vaughan , David Hilbert
CPC classification number: C07K16/2875 , A61K35/12 , A61K47/6849 , A61K49/0004 , A61K2039/505 , C07K14/52 , C07K14/70575 , C07K2317/21 , C07K2317/622 , G01N33/5008 , G01N33/5011 , G01N33/5052 , G01N33/5091 , G01N33/564 , G01N33/574 , G01N33/68
Abstract: The present invention relates to antibodies and related molecules that immunospecifically bind to B Lymphocyte Stimulator. The present invention also relates to methods and compositions for detecting or diagnosing a disease or disorder associated vith aberrant B Lymphocyte Stimulator expression or inappropriate function of B Lymphocyte Stimulator comprising antibodies or fragments or variants thereof or related molecules that immunospecifically bind to B Lymphocyte Stimulator. The present invention further relates to methods and compositions for preventing, treating or ameliorating a disease or disorder associated with aberrant B Lymphocyte Stimulator expression or inappropriate B Lymphocyte Stimulator function comprising administering to an animal an effective amount of one or more antibodies or fragments or variants thereof or related molecules that immunospecifically bind to B Lymphocyte Stimulator.
Abstract translation: 本发明涉及免疫特异性结合B淋巴细胞刺激物的抗体和相关分子。 本发明还涉及用于检测或诊断与异常B淋巴细胞刺激物表达相关的疾病或病症的方法和组合物，其包含抗体或其片段或变体，或免疫特异性结合B淋巴细胞刺激物的相关分子的B淋巴细胞刺激物的不适当功能。 本发明还涉及用于预防，治疗或改善与异常B淋巴细胞刺激物表达或不适当B淋巴细胞刺激因子功能相关的疾病或病症的方法和组合物，包括向动物施用有效量的一种或多种抗体或其片段或变体 或免疫特异性结合B淋巴细胞刺激物的相关分子。
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