Invention Application
US20050038020A1 Adamantylglycine-based inhibitors of dipeptidyl peptidase IV and methods
有权
基于金刚烷基甘氨酸的二肽基肽酶IV抑制剂及方法
- Patent Title: Adamantylglycine-based inhibitors of dipeptidyl peptidase IV and methods
- Patent Title (中): 基于金刚烷基甘氨酸的二肽基肽酶IV抑制剂及方法
-
Application No.: US10899641Application Date: 2004-07-27
-
Publication No.: US20050038020A1Publication Date: 2005-02-17
- Inventor: Lawrence Hamann , Ashish Khanna , Mark Kirby , David Magnin , Ligaya Simpkins , James Sutton , Jeffrey Robl
- Applicant: Lawrence Hamann , Ashish Khanna , Mark Kirby , David Magnin , Ligaya Simpkins , James Sutton , Jeffrey Robl
- Main IPC: C07C255/46
- IPC: C07C255/46 ; C07C255/47 ; C07D207/16 ; C07D209/52 ; C07D277/04 ; C07D295/185 ; C07D279/12 ; A61K31/445 ; A61K31/54 ; C07D211/06 ; C07D265/30
Abstract:
Compounds are provided having the formula (I) wherein: n is 0, 1 or 2; m is 0, 1 or 2; the sum of n+m less then or equal to 2; the dashed bonds forming a cyclopropyl ring can only be present when Y is CH; X is H or CN; Y is CH, CH2, CHF, CF2, O, S, SO, or SO2; and A is adamantyl. Further provided are methods of using such compounds for the treatment of diabetes and related diseases, and to pharmaceutical compositions containing such compounds.
Public/Granted literature
- US06995183B2 Adamantylglycine-based inhibitors of dipeptidyl peptidase IV and methods Public/Granted day:2006-02-07
Information query
