发明申请
- 专利标题： Reducing protein a leaching during protein a affinity chromatography
- 专利标题（中）： 在蛋白质亲和层析中减少蛋白质浸出
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申请号： US10877532申请日： 2004-06-24
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公开(公告)号： US20050038231A1公开(公告)日： 2005-02-17
- 发明人: Robert Fahrner , Amy Laverdiere , Paul McDonald , Rhona O'Leary
- 申请人： Robert Fahrner , Amy Laverdiere , Paul McDonald , Rhona O'Leary
- 申请人地址： US CA South San Francisco
- 专利权人： Genentech, Inc.
- 当前专利权人： Genentech, Inc.
- 当前专利权人地址： US CA South San Francisco
- 主分类号： C07K16/06
- IPC分类号： C07K16/06 ; C07K16/30 ; A61K38/00 ; C07K16/00
摘要：
A method for reducing leaching of protein A during protein A affinity chromatography is described which involves reducing temperature or pH of, or by adding one or more protease inhibitors to, a composition that is subjected to protein A affinity chromatography.
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