发明申请
US20050043344A1 Heteroarylalkanoic acids as integrin receptor antagonists derivatives
审中-公开
杂芳基链烷酸作为整联蛋白受体拮抗剂衍生物
- 专利标题： Heteroarylalkanoic acids as integrin receptor antagonists derivatives
- 专利标题（中）： 杂芳基链烷酸作为整联蛋白受体拮抗剂衍生物
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申请号： US10743354申请日： 2003-12-22
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公开(公告)号： US20050043344A1公开(公告)日： 2005-02-24
- 发明人: Mark Boys , Lori Schretzman , Michael Tollefson , Nizal Chandrakumar , Ish Khanna , Maria Nguyen , Victoria Downs , Scott Mohler , Glen Gesicki , Thomas Penning , Barbara Chen , Yaping Wang , Albert Khilevich , Bipinchandra Desai , Yi Yu , John Wendt , Heather Stenmark , Hongwei Wu , Renee Huff , Srinivasan Nagarajan , Balekudru Devadas , Hwang-Fun Lu , Mark Russell , Dale Spangler , Mihir Parikh
- 申请人： Mark Boys , Lori Schretzman , Michael Tollefson , Nizal Chandrakumar , Ish Khanna , Maria Nguyen , Victoria Downs , Scott Mohler , Glen Gesicki , Thomas Penning , Barbara Chen , Yaping Wang , Albert Khilevich , Bipinchandra Desai , Yi Yu , John Wendt , Heather Stenmark , Hongwei Wu , Renee Huff , Srinivasan Nagarajan , Balekudru Devadas , Hwang-Fun Lu , Mark Russell , Dale Spangler , Mihir Parikh
- 专利权人： Pharmacia Corporation
- 当前专利权人： Pharmacia Corporation
- 主分类号： A61K31/4245
- IPC分类号： A61K31/4245 ; A61K31/4745 ; A61P19/02 ; A61P19/10 ; A61P27/00 ; A61P35/00 ; A61P35/04 ; A61P43/00
摘要：
The present invention relates to pharmaceutical compositions comprising compounds of the Formula I, or a pharmaceutically acceptable salt thereof, and methods of selectively inhibiting or antagonizing the αVβ3 and/or the αVβ5 integrin without significantly inhibiting the αVβ6 integrin.
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