发明申请
US20050048627A1 Human serum albumin-TIMP2 fusion protein, a polynucleotide encoding the same and a method of producing the human serum albumin-TIMP2 fusion protein
有权
人血清白蛋白-TMP2融合蛋白，编码其的多核苷酸和产生人血清白蛋白-TMP2融合蛋白的方法
- 专利标题： Human serum albumin-TIMP2 fusion protein, a polynucleotide encoding the same and a method of producing the human serum albumin-TIMP2 fusion protein
- 专利标题（中）： 人血清白蛋白-TMP2融合蛋白，编码其的多核苷酸和产生人血清白蛋白-TMP2融合蛋白的方法
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申请号： US10888887申请日： 2004-07-08
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公开(公告)号： US20050048627A1公开(公告)日： 2005-03-03
- 发明人: Jeong-Yoon Kim , Min-Young Kim , Eun-Kyu Park , Jae-Young Chang , Hyun Kang
- 申请人： Jeong-Yoon Kim , Min-Young Kim , Eun-Kyu Park , Jae-Young Chang , Hyun Kang
- 优先权： KR10-2002-0001057 20020108
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; C07K14/81 ; C12N15/14 ; C07H21/04 ; C07K14/53 ; C12P21/02 ; C12P21/04
摘要：
The present invention provides a human serum albumin-TIMP2 fusion protein having the amino acid sequence set forth in SEQ ID NO. 10, a polynucleotide encoding the same and a vector comprising the polynucleotide, a host cell transformed with the vector, a method for producing the human serum albumin-TIMP2 fusion protein and a pharmaceutical composition comprising the human serum albumin-TIMP2 fusion protein. The human serum albumin-TIMP2 fusion protein is stable and retains the activity of TIMP2, thus it can be used as a pharmaceutical composition to treat diseases related to angiogenesis and/or metastasis of cancer cells.
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