Invention Application
US20050079224A1 Residual solvent extraction method and microparticles produced thereby
审中-公开
残留溶剂萃取方法和由此产生的微粒
- Patent Title: Residual solvent extraction method and microparticles produced thereby
- Patent Title (中): 残留溶剂萃取方法和由此产生的微粒
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Application No.: US10956092Application Date: 2004-10-04
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Publication No.: US20050079224A1Publication Date: 2005-04-14
- Inventor: Michael Rickey , J. Ramstack , Rajesh Kumar
- Applicant: Michael Rickey , J. Ramstack , Rajesh Kumar
- Applicant Address: US MA Cambridge
- Assignee: Alkermes Controlled Therapeutics Inc. II
- Current Assignee: Alkermes Controlled Therapeutics Inc. II
- Current Assignee Address: US MA Cambridge
- Priority: JP2000-283721 20000919
- Main IPC: B65D5/462
- IPC: B65D5/462 ; A61K9/16 ; A61K31/519 ; A61K38/00 ; A61K38/04 ; A61K47/32 ; A61K47/34 ; B01J8/02 ; B01J13/08 ; B01J13/12 ; B01J13/20 ; B01J14/00 ; B01J19/12 ; B01J19/24 ; B65D5/46 ; B65D5/465 ; B65D71/00 ; B65D71/36 ; A61K38/09 ; A61K9/50 ; B01J13/02 ; B01J13/04
Abstract:
Methods for preparing microparticles having reduced residual solvent levels. Microparticles are contacted with a non-aqueous washing system to reduce the level of residual solvent in the microparticles. Preferred non-aqueous washing systems include 100% ethanol and a blend of ethanol and heptane. A solvent blend of a hardening solvent and a washing solvent can be used to harden and wash microparticles in a single step, thereby eliminating the need for a post-hardening wash step.
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