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1.发明申请公开(公告)号：US20050079224A1
公开(公告)日：2005-04-14
申请号：US10956092
申请日：2004-10-04
Applicant: Michael Rickey , J. Ramstack , Rajesh Kumar
Inventor： Michael Rickey , J. Ramstack , Rajesh Kumar
IPC: B65D5/462 , A61K9/16 , A61K31/519 , A61K38/00 , A61K38/04 , A61K47/32 , A61K47/34 , B01J8/02 , B01J13/08 , B01J13/12 , B01J13/20 , B01J14/00 , B01J19/12 , B01J19/24 , B65D5/46 , B65D5/465 , B65D71/00 , B65D71/36 , A61K38/09 , A61K9/50 , B01J13/02 , B01J13/04
CPC classification number: A61K38/09 , A61K9/1641 , A61K9/1647 , A61K9/1682 , A61K9/1694 , A61K9/5089 , A61K31/519 , B01J8/025 , B01J13/08 , B01J13/12 , B01J13/206 , B01J14/00 , B01J19/121 , B01J19/122 , B01J19/2415 , B01J2219/0877
Abstract: Methods for preparing microparticles having reduced residual solvent levels. Microparticles are contacted with a non-aqueous washing system to reduce the level of residual solvent in the microparticles. Preferred non-aqueous washing systems include 100% ethanol and a blend of ethanol and heptane. A solvent blend of a hardening solvent and a washing solvent can be used to harden and wash microparticles in a single step, thereby eliminating the need for a post-hardening wash step.
Abstract translation: 制备具有降低的残留溶剂水平的微粒的方法。 微粒与非水洗涤体系接触以降低微粒中残留溶剂的含量。 优选的非水洗涤系统包括100％乙醇和乙醇与庚烷的混合物。 可以使用硬化溶剂和洗涤溶剂的溶剂共混物在一个步骤中硬化和洗涤微粒，从而不需要后硬化洗涤步骤。
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2.发明申请Method for preparing microparticles having a selected polymer molecular weight 审中-公开具有选择的聚合物分子量的微粒的制备方法公开(公告)号：US20080058502A1
公开(公告)日：2008-03-06
申请号：US11826693
申请日：2007-07-17
Applicant: Steven Wright , Michael Rickey , J. Ramstack , Shawn Lyons , Joyce Hotz
Inventor： Steven Wright , Michael Rickey , J. Ramstack , Shawn Lyons , Joyce Hotz
IPC: C08F6/06
CPC classification number: A61K31/519 , A61K9/1647 , A61K9/1694 , B01J13/02
Abstract: A method for preparing microparticles having a selected polymer molecular weight. The hold time and temperature of a solution containing a nucleophilic compound and a polymer having a starting molecular weight are controlled in order to control the molecular weight of the polymer in the finished microparticle product. In this manner, a selected polymer molecular weight in the finished microparticle product can be achieved from a variety of starting material molecular weights.
Abstract translation: 一种制备具有选定的聚合物分子量的微粒的方法。 控制包含亲核化合物和具有起始分子量的聚合物的溶液的保持时间和温度以控制成品微粒产物中的聚合物的分子量。 以这种方式，可以从各种原料分子量获得成品微粒产物中所选择的聚合物分子量。
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3.发明申请公开(公告)号：US20080050447A1
公开(公告)日：2008-02-28
申请号：US11826383
申请日：2007-07-13
Applicant: Michael Rickey , J. Ramstack , Rajesh Kumar
Inventor： Michael Rickey , J. Ramstack , Rajesh Kumar
CPC classification number: A61K38/09 , A61K9/1641 , A61K9/1647 , A61K9/1682 , A61K9/1694 , A61K9/5089 , A61K31/519 , B01J8/025 , B01J13/08 , B01J13/12 , B01J13/206 , B01J14/00 , B01J19/121 , B01J19/122 , B01J19/2415 , B01J2219/0877
Abstract: Methods for preparing microparticles having reduced residual solvent levels. Microparticles are contacted with a non-aqueous washing system to reduce the level of residual solvent in the microparticles. Preferred non-aqueous washing systems include 100% ethanol and a blend of ethanol and heptane. A solvent blend of a hardening solvent and a washing solvent can be used to harden and wash microparticles in a single step, thereby eliminating the need for a post-hardening wash step.
Abstract translation: 制备具有降低的残留溶剂水平的微粒的方法。 微粒与非水洗涤体系接触以降低微粒中残留溶剂的含量。 优选的非水洗涤系统包括100％乙醇和乙醇与庚烷的混合物。 可以使用硬化溶剂和洗涤溶剂的溶剂共混物在一个步骤中硬化和洗涤微粒，从而不需要后硬化洗涤步骤。
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公开(公告)号：US20080044485A1
公开(公告)日：2008-02-21
申请号：US11826994
申请日：2007-07-19
Applicant: J. Ramstack , M. Gary Riley , Stephen Zale , Joyce Hotz , Olufunmi Johnson
Inventor： J. Ramstack , M. Gary Riley , Stephen Zale , Joyce Hotz , Olufunmi Johnson
CPC classification number: A61K47/34 , A61K9/0019 , A61K9/1641 , A61K9/1647 , A61K9/1658 , A61K31/505 , A61K47/26 , A61K47/38
Abstract: Injectable compositions having improved injectability. The injectable compositions include microparticles suspended in an aqueous injection vehicle having a viscosity of at least 20 cp at 20° C. The increased viscosity of the injection vehicle that constitutes the fluid phase of the suspension significantly reduces in vivo injectability failures. The injectable compositions can be made by mixing dry microparticles with an aqueous injection vehicle to form a suspension, and then mixing the suspension with a viscosity enhancing agent to increase the viscosity of the fluid phase of the suspension to the desired level for improved injectability.
Abstract translation: 具有改进的注射性的可注射组合物。 可注射组合物包括悬浮在20摄氏度粘度至少为20cp的含水注射用载体中的微粒。构成悬浮液相的注射载体的增加的粘度显着降低体内注射性失败。 可注射组合物可以通过将干燥微粒与水性注射载体混合以形成悬浮液，然后将悬浮液与粘度增强剂混合以将悬浮液的流体相的粘度增加至所需水平以改善注射性，从而制备。
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Patent Agency Ranking
公开(公告)号：US20080051561A1
公开(公告)日：2008-02-28
申请号：US11826382
申请日：2007-07-13
Applicant: Michael Rickey , J. Ramstack , Rajesh Kumar
Inventor： Michael Rickey , J. Ramstack , Rajesh Kumar
IPC: C07K14/00
CPC classification number: A61K38/09 , A61K9/1641 , A61K9/1647 , A61K9/1682 , A61K9/1694 , A61K9/5089 , A61K31/519 , B01J8/025 , B01J13/08 , B01J13/12 , B01J13/206 , B01J14/00 , B01J19/121 , B01J19/122 , B01J19/2415 , B01J2219/0877
Abstract: Methods for preparing microparticles having reduced residual solvent levels. Microparticles are contacted with a non-aqueous washing system to reduce the level of residual solvent in the microparticles. Preferred non-aqueous washing systems include 100% ethanol and a blend of ethanol and heptane. A solvent blend of a hardening solvent and a washing solvent can be used to harden and wash microparticles in a single step, thereby eliminating the need for a post-hardening wash step.
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公开(公告)号：US20070196499A1
公开(公告)日：2007-08-23
申请号：US11785638
申请日：2007-04-19
Applicant: Michael Rickey , J. Ramstack , Rajesh Kumar
Inventor： Michael Rickey , J. Ramstack , Rajesh Kumar
CPC classification number: A61K38/09 , A61K9/1641 , A61K9/1647 , A61K9/1682 , A61K9/1694 , A61K9/5089 , A61K31/519 , B01J8/025 , B01J13/08 , B01J13/12 , B01J13/206 , B01J14/00 , B01J19/121 , B01J19/122 , B01J19/2415 , B01J2219/0877
Abstract: Methods for preparing microparticles having reduced residual solvent levels. Microparticles are contacted with a non-aqueous washing system to reduce the level of residual solvent in the microparticles. Preferred non-aqueous washing systems include 100% ethanol and a blend of ethanol and heptane. A solvent blend of a hardening solvent and a washing solvent can be used to harden and wash microparticles in a single step, thereby eliminating the need for a post-hardening wash step.
Abstract translation: 制备具有降低的残留溶剂水平的微粒的方法。 微粒与非水洗涤体系接触以降低微粒中残留溶剂的含量。 优选的非水洗涤系统包括100％乙醇和乙醇与庚烷的混合物。 可以使用硬化溶剂和洗涤溶剂的溶剂共混物在一个步骤中硬化和洗涤微粒，从而不需要后硬化洗涤步骤。
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7.发明申请Preparation of biodegradable, biocompatible microparticles containing a biologically active agent 审中-公开制备含有生物活性剂的可生物降解的生物相容性微粒公开(公告)号：US20050276859A1
公开(公告)日：2005-12-15
申请号：US11129434
申请日：2005-05-16
Applicant: Michael Rickey , J. Ramstack , Danny Lewis
Inventor： Michael Rickey , J. Ramstack , Danny Lewis
IPC: A61K9/56 , A61K9/14 , A61K9/16 , A61K9/50 , A61K9/58 , A61K31/505 , A61K31/517 , A61K31/519 , A61K31/529 , A61K47/30 , A61K47/34 , B01J13/04 , B01J13/06 , B29B9/00
CPC classification number: B01J13/04 , A61K9/1647 , A61K9/1694 , A61K9/5089 , A61K31/519 , Y10T428/2985
Abstract: A method for preparing biodegradable, biocompatible microparticles. A first phase is prepared that includes a biodegradable, biocompatible polymer, an active agent, and a solvent. A second phase is prepared. The first and second phases are combined to form an emulsion in which the first phase is discontinuous and the second phase is continuous. The discontinuous first phase is separated from the continuous second phase. The residual level of solvent in the discontinuous first phase is reduced to less than about 2% by weight.
Abstract translation: 一种制备可生物降解的生物相容性微粒的方法。 制备包含可生物降解的生物相容性聚合物，活性剂和溶剂的第一相。 准备第二阶段 第一和第二相组合形成乳液，其中第一相是不连续的，第二相是连续的。 不连续的第一相与连续的第二相分离。 不连续第一相中溶剂的残留量减少到小于约2重量％。
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公开(公告)号：US20080044478A1
公开(公告)日：2008-02-21
申请号：US11826995
申请日：2007-07-19
Applicant: J. Ramstack , M. Gary Riley , Stephen Zale , Joyce Hotz , Olufunmi Johnson
Inventor： J. Ramstack , M. Gary Riley , Stephen Zale , Joyce Hotz , Olufunmi Johnson
CPC classification number: A61K47/34 , A61K9/0019 , A61K9/1641 , A61K9/1647 , A61K9/1658 , A61K31/505 , A61K47/26 , A61K47/38
Abstract: Injectable compositions having improved injectability. The injectable compositions include microparticles suspended in an aqueous injection vehicle having a viscosity of at least 20 cp at 20° C. The increased viscosity of the injection vehicle that constitutes the fluid phase of the suspension significantly reduces in vivo injectability failures. The injectable compositions can be made by mixing dry microparticles with an aqueous injection vehicle to form a suspension, and then mixing the suspension with a viscosity enhancing agent to increase the viscosity of the fluid phase of the suspension to the desired level for improved injectability.
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公开(公告)号：US20060142320A1
公开(公告)日：2006-06-29
申请号：US10860608
申请日：2004-06-03
Applicant: Harry Brittain , David Dickason , Joyce Hotz , Shawn Lyons , J. Ramstack , Steven Wright
Inventor： Harry Brittain , David Dickason , Joyce Hotz , Shawn Lyons , J. Ramstack , Steven Wright
IPC: C07D489/02 , A61K31/485
CPC classification number: A61K31/485 , C07B2200/13 , C07C19/03 , C07D489/06 , C07D489/08
Abstract: This invention relates to the discovery of novel polymorphic forms of naltrexone, including solvates, hydrates, anhydrous and other crystalline forms and combinations thereof. These novel forms of naltrexone impart advantages in pharmaceutical formulations incorporating them, including sustained release, or long acting, formulations.
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