发明申请
US20050080026A1 Mnk kinase homologous proteins involved in the regulation of energy homeostasis and organelle metabolism
审中-公开
参与调节能量稳态和细胞器代谢的Mnk激酶同源蛋白
- 专利标题： Mnk kinase homologous proteins involved in the regulation of energy homeostasis and organelle metabolism
- 专利标题（中）： 参与调节能量稳态和细胞器代谢的Mnk激酶同源蛋白
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申请号： US10494010申请日： 2002-10-29
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公开(公告)号： US20050080026A1公开(公告)日： 2005-04-14
- 发明人: Arnd Steuernagel , Karsten Eulenberg , Gunter Bronner , Thomas Ciossek , Bettina Rudolph , Dorothea Rudolph , Funmi Belgore , Stefan Jakel , Christoph Meyer
- 申请人： Arnd Steuernagel , Karsten Eulenberg , Gunter Bronner , Thomas Ciossek , Bettina Rudolph , Dorothea Rudolph , Funmi Belgore , Stefan Jakel , Christoph Meyer
- 优先权： EP011258126 20011029; EP020110730 20020517
- 国际申请： PCT/EP02/12075 WO 20021029
- 主分类号： A01K67/027
- IPC分类号： A01K67/027 ; A61K31/519 ; A61K31/553 ; A61K38/45 ; A61K39/395 ; A61K48/00 ; A61P1/16 ; A61P3/00 ; A61P3/04 ; A61P3/06 ; A61P3/10 ; A61P7/00 ; A61P9/10 ; A61P9/12 ; A61P11/00 ; A61P19/02 ; A61P25/18 ; A61P25/28 ; A61P35/00 ; A61P39/06 ; C12N5/10 ; C12N9/12 ; C12N15/09 ; C12Q1/48 ; C12R1/91 ; G01N33/15 ; G01N33/50 ; G01N33/53 ; C12Q1/68
摘要：
The present invention discloses Mnk homologous proteins regulating the energy homeostasis, the metabolism of triglycerides, and/or is contributing to membrane stability and/or function of organelles, and polynucleotides, which identify and encode the proteins disclosed in this invention. The invention also relates to the use of these sequences in the diagnosis, study, prevention, and treatment of diseases and disorders related to body-weight regulation and thermogenesis, for example, but not limited to, metabolic diseases such as obesity, as well as related disorders such as eating disorder, cachexia, diabetes mellitus, hypertension, coronary heart disease, hypercholesterolemia, dyslipidemia, osteoarthritis, gallstones, and sleep apnea, and disorders related to ROS defence, such as diabetes mellitus, neurodegenerative disorders, and cancer, e.g. cancers of the reproductive organs, and others.