发明申请
- 专利标题: Aromatic amino acid derivates and medicinal compositions
- 专利标题(中): 芳香族氨基酸衍生物和药物组合物
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申请号: US10503125申请日: 2003-02-03
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公开(公告)号: US20050119256A1公开(公告)日: 2005-06-02
- 发明人: Hitoshi Endo , Yoshikatsu Kanai , Kenji Tsujihara , Kunio Saito
- 申请人: Hitoshi Endo , Yoshikatsu Kanai , Kenji Tsujihara , Kunio Saito
- 申请人地址: JP Kanagawa 229-0022
- 专利权人: Hitoshi Endou
- 当前专利权人: Hitoshi Endou
- 当前专利权人地址: JP Kanagawa 229-0022
- 优先权: JP2002-031216 20020207
- 国际申请: PCT/JP03/01081 WO 20030203
- 主分类号: A61P35/00
- IPC分类号: A61P35/00 ; A61P43/00 ; C07C229/36 ; C07C233/47 ; C07C233/69 ; C07C255/54 ; C07C271/10 ; C07D207/32 ; C07D207/325 ; C07D209/08 ; C07D213/30 ; C07D213/74 ; C07D215/14 ; C07D235/18 ; C07D239/42 ; C07D263/32 ; C07D263/56 ; C07D265/36 ; C07D277/24 ; C07D277/66 ; C07D307/79 ; C07D307/82 ; C07D307/83 ; C07D307/91 ; C07D311/30 ; C07D401/04 ; C07D413/04 ; C07D417/04 ; C07D471/06 ; A61K31/54 ; A61K31/4745
摘要:
1. An aromatic amino acid derivative represented by the formula (I) or its pharmacologically acceptable salt: wherein, R1 is a hydrogen atom or an amino-protecting group, R2 is a halogen atom or an alkyl, aralkyl or aryl group, R3 is {circle over (1)} a hydrogen atom, {circle over (2)} an aroylamino group, {circle over (3)} a phenyl group substituted with lower alkyl, phenyl, phenoxy, etc. {circle over (4)} a naphthyl or tetrahydronaphthyl group optionally substituted with hydroxy, lower alkoxy or di(lower)alkylamino, {circle over (5)} an unsaturated mono-cyclic heterocyclic group containing N, O and/or S substituted with lower alkyl, phenyl, naphthyl or tetrahydroquinolyl, {circle over (6)} an unsaturated or partially saturated condensed heterocyclic group containing N, O and/or S, optionally substituted with oxo, carboxy, amino, lower alkyl, etc.; X is a halogen atom, an alkyl group or an alkoxy group; Y is oxygen atom or nitrogen atom; I is 0 or 1; m is 0, 1 or 2; n is an integer of 0-5. This compound can inhibit a transporter (LAT1) of essential amino acid which is one of main nutrition for cancer cells and accordingly cause drain of the essential amino acid on the cancer cells and finally can prohibit the multiplication of cancer cells.
公开/授权文献
- US07345068B2 Aromatic amino acid derivatives and medicinal compositions 公开/授权日:2008-03-18
信息查询
IPC分类:
A | 人类生活必需 |
A61 | 医学或兽医学;卫生学 |
A61P | 化合物或药物制剂的特定治疗活性 |
A61P35/00 | 抗肿瘤药 |