发明申请
- 专利标题： Method for producing recombinant proteins in micro-organisms
- 专利标题（中）： 在微生物中生产重组蛋白的方法
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申请号： US10503910申请日： 2003-02-06
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公开(公告)号： US20050124036A1公开(公告)日： 2005-06-09
- 发明人: Rudy Susilo , Hans Korting , Hans Gassen , Martin Hils , Ralf Pasternack
- 申请人： Rudy Susilo , Hans Korting , Hans Gassen , Martin Hils , Ralf Pasternack
- 优先权： EP02002716.5 20020206
- 国际申请： PCT/DE03/00341 WO 20030206
- 主分类号： C12N15/09
- IPC分类号： C12N15/09 ; A61K9/06 ; A61K9/70 ; A61K31/616 ; A61K31/727 ; A61K38/43 ; A61K38/48 ; A61K45/00 ; A61P7/00 ; A61P7/02 ; A61P9/00 ; A61P9/10 ; A61P17/02 ; A61P27/02 ; C08B37/10 ; C12N1/15 ; C12N1/19 ; C12N9/68 ; C12N15/57 ; C12N15/62 ; C12Q1/37 ; C07H21/04 ; C12N1/18 ; C12N9/48 ; C12N15/74 ; C12P21/04
摘要：
The invention relates to a method for producing a recombinant functional plasminogen in micro-organisms, and to a method for identifying plasminogen activators. The nucleic acid sequence coding for the fuctional part of the plasminogen is fused with a nucleic acid molecule coding for at least one signal peptide. The nucleic acid molecule coding for the plasminogen and the nucleic acid molecule coding for the signal peptide are combined with codons for interfaces of proteases which ensure the separation of the signal peptide. The recombinant plasminogen or the corresponding plasmin is suitable for treating wounds which are slow to heal or not healing, by application of the enzyme in an appropriate formulation.
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