公开(公告)号：US20120156361A1

公开(公告)日：2012-06-21

申请号：US13403335

申请日：2012-02-23

申请人： Achim Müller ,  Monika Knuth ,  Ralf Pasternack ,  Jens Zotzel ,  Christine Reiff

发明人： Achim Müller ,  Monika Knuth ,  Ralf Pasternack ,  Jens Zotzel ,  Christine Reiff

IPC分类号： B05D3/10

CPC分类号： B29D11/00865 ,  G02B1/043 ,  Y10S514/839

摘要： The invention relates to a process for producing biomedical articles, in particular, silicone hydrogel contact lenses having durable hydrophilic chitosan coating. The chitosan coating is covalently attached to the medical device by performing a crosslinking reaction between chitosan and the carboxylic groups on the surface of a medical device directly in a sealed package during autoclave. The coated biomedical articles obtainable by the process of the invention have desirable characteristics regarding adherence to the substrate, durability, hydrophilicity, wettability, biocompatibility and permeability and are thus especially useful in the field of ophthalmic devices.

摘要翻译： 本发明涉及一种用于生产生物医学制品的方法，特别是具有持久的亲水性壳聚糖涂层的硅酮水凝胶隐形眼镜。 壳聚糖涂层通过在高压釜中直接在密封包装中在壳聚糖和医疗器械表面上的羧基之间进行交联反应而共价连接到医疗装置上。 通过本发明的方法可获得的涂覆的生物医学制品具有关于对基底的粘附，耐久性，亲水性，润湿性，生物相容性和渗透性的期望特性，因此在眼科装置领域中特别有用。

公开(公告)号：US20090029413A1

公开(公告)日：2009-01-29

申请号：US12074329

申请日：2008-03-03

申请人： Achim Muller ,  Monika Knuth ,  Katharina Schmid ,  Ralf Pasternack ,  Jens Zotzel ,  Kai Oertel ,  Christine Reiff, geb. Schmitt ,  Hans-Lothar Fuchsbauer

发明人： Achim Muller ,  Monika Knuth ,  Katharina Schmid ,  Ralf Pasternack ,  Jens Zotzel ,  Kai Oertel ,  Christine Reiff, geb. Schmitt ,  Hans-Lothar Fuchsbauer

IPC分类号： C12P21/04 ,  C12P1/00 ,  C07K7/00

CPC分类号： C08J7/047 ,  A61F2/14 ,  A61L27/28 ,  A61L27/34 ,  A61L27/50 ,  C08J2489/00 ,  G02C7/04 ,  C08L89/00

摘要： The invention relates to a process for the manufacture of a composite materials comprising the steps of (a) providing a hydrophobic organic bulk material, and (b) applying a hydrophilic surface coating on the hydrophobic organic bulk material by first non-covalently attaching to the surface of the bulk material a water-soluble peptide comprising a hydrophobic moiety; and then chemically or enzymatically crosslinking said water-soluble peptide. The composite materials manufactured according to the process of the invention have desirable characteristics regarding adherence to the substrate, durability, hydrophilicity, wettability, biocompatibility and permeability and are thus particularly useful as ophthalmic devices.

摘要翻译： 本发明涉及一种制备复合材料的方法，包括以下步骤：（a）提供疏水性有机体材料，和（b）通过首先非共价连接到疏水性有机大块材料 本体材料的表面是包含疏水部分的水溶性肽; 然后化学或酶促交联所述水溶性肽。 根据本发明的方法制造的复合材料具有关于对基材的粘附性，耐久性，亲水性，润湿性，生物相容性和渗透性的期望特性，因此特别适用于眼科装置。

公开(公告)号：US08808980B2

公开(公告)日：2014-08-19

申请号：US13509225

申请日：2010-11-11

申请人： Martin Hils ,  Ralf Pasternack ,  Johannes Weber

发明人： Martin Hils ,  Ralf Pasternack ,  Johannes Weber

IPC分类号： C12Q1/00

CPC分类号： G01N33/564 ,  C12Q1/52 ,  G01N2333/91085

摘要： The present invention relates to the diagnosis of disorders or dysfunctions characterized by autoimmune responses to the enzyme class of transglutaminases. The present invention provides a novel open structure of the transglutaminases in a stabilized form which renders new epitopes accessible for antibody-binding.

摘要翻译： 本发明涉及特征在于对转谷氨酰胺酶类的自身免疫应答的病症或功能障碍的诊断。 本发明提供了稳定形式的转谷氨酰胺酶的新型开放结构，其使新的抗原决定簇可用于抗体结合。

公开(公告)号：US08647699B2

公开(公告)日：2014-02-11

申请号：US13403335

申请日：2012-02-23

申请人： Achim Müller ,  Monika Knuth ,  Ralf Pasternack ,  Jens Zotzel ,  Christine Reiff

发明人： Achim Müller ,  Monika Knuth ,  Ralf Pasternack ,  Jens Zotzel ,  Christine Reiff

IPC分类号： B05D3/10 ,  B29D11/00 ,  A61K9/00

CPC分类号： B29D11/00865 ,  G02B1/043 ,  Y10S514/839

摘要： The invention relates to a process for producing biomedical articles, in particular, silicone hydrogel contact lenses having durable hydrophilic chitosan coating. The chitosan coating is covalently attached to the medical device by performing a crosslinking reaction between chitosan and the carboxylic groups on the surface of a medical device directly in a sealed package during autoclave. The coated biomedical articles obtainable by the process of the invention have desirable characteristics regarding adherence to the substrate, durability, hydrophilicity, wettability, biocompatibility and permeability and are thus especially useful in the field of ophthalmic devices.

摘要翻译： 本发明涉及一种用于生产生物医学制品的方法，特别是具有持久的亲水性壳聚糖涂层的硅酮水凝胶隐形眼镜。 壳聚糖涂层通过在高压釜中直接在密封包装中在壳聚糖和医疗器械表面上的羧基之间进行交联反应而共价连接到医疗装置上。 通过本发明的方法可获得的涂覆的生物医学制品具有关于对基底的粘附，耐久性，亲水性，润湿性，生物相容性和渗透性的期望特性，因此在眼科装置领域中特别有用。

公开(公告)号：US08142835B2

公开(公告)日：2012-03-27

申请号：US12321443

申请日：2009-01-21

申请人： Achim Müller ,  Monika Knuth ,  Ralf Pasternack ,  Jens Zotzel ,  Christine Reiff

发明人： Achim Müller ,  Monika Knuth ,  Ralf Pasternack ,  Jens Zotzel ,  Christine Reiff

IPC分类号： B05D3/10 ,  B29D11/00 ,  A61K9/00

CPC分类号： B29D11/00865 ,  G02B1/043 ,  Y10S514/839

摘要： The invention relates to a process for producing biomedical articles, in particular, silicone hydrogel contact lenses having durable hydrophilic chitosan coating. The chitosan coating is covalently attached to the medical device by performing a crosslinking reaction between chitosan and the carboxylic groups on the surface of a medical device directly in a sealed package during autoclave. The coated biomedical articles obtainable by the process of the invention have desirable characteristics regarding adherence to the substrate, durability, hydrophilicity, wettability, biocompatibility and permeability and are thus especially useful in the field of ophthalmic devices.

摘要翻译： 本发明涉及一种用于生产生物医学制品的方法，特别是具有持久的亲水性壳聚糖涂层的硅酮水凝胶隐形眼镜。 壳聚糖涂层通过在高压釜中直接在密封包装中在壳聚糖和医疗器械表面上的羧基之间进行交联反应而共价连接到医疗装置上。 通过本发明的方法可获得的涂覆的生物医学制品具有关于对基底的粘附，耐久性，亲水性，润湿性，生物相容性和渗透性的期望特性，因此在眼科装置领域中特别有用。

公开(公告)号：US20090186229A1

公开(公告)日：2009-07-23

申请号：US12321443

申请日：2009-01-21

申请人： Achim Muller ,  Monika Knuth ,  Ralf Pasternack ,  Jens Zotzel ,  Christine Reiff

发明人： Achim Muller ,  Monika Knuth ,  Ralf Pasternack ,  Jens Zotzel ,  Christine Reiff

IPC分类号： A61L33/00 ,  B32B13/04

CPC分类号： B29D11/00865 ,  G02B1/043 ,  Y10S514/839

摘要： The invention relates to a process for producing biomedical articles, in particular, silicone hydrogel contact lenses having durable hydrophilic chitosan coating. The chitosan coating is covalently attached to the medical device by performing a crosslinking reaction between chitosan and the carboxylic groups on the surface of a medical device directly in a sealed package during autoclave. The coated biomedical articles obtainable by the process of the invention have desirable characteristics regarding adherence to the substrate, durability, hydrophilicity, wettability, biocompatibility and permeability and are thus especially useful in the field of ophthalmic devices.

摘要翻译： 本发明涉及一种用于生产生物医学制品的方法，特别是具有持久的亲水性壳聚糖涂层的硅酮水凝胶隐形眼镜。 壳聚糖涂层通过在高压釜中直接在密封包装中在壳聚糖和医疗器械表面上的羧基之间进行交联反应而共价连接到医疗装置上。 通过本发明的方法可获得的涂覆的生物医学制品具有关于对基底的粘附，耐久性，亲水性，润湿性，生物相容性和渗透性的期望特性，因此在眼科装置领域中特别有用。

公开(公告)号：US09260680B2

公开(公告)日：2016-02-16

申请号：US11666718

申请日：2005-11-10

申请人： Ralf Pasternack ,  Stefan Marx ,  Dominik Jordan

发明人： Ralf Pasternack ,  Stefan Marx ,  Dominik Jordan

IPC分类号： A23L2/84 ,  C12C5/00 ,  A23L1/015 ,  A23L1/30 ,  C12C12/00

CPC分类号： C12C5/004 ,  A23L2/84 ,  A23L5/25 ,  A23L33/135 ,  C12C12/00 ,  C12Y101/03005 ,  C12Y110/03002 ,  C12Y111/01007 ,  C12Y114/18001 ,  C12Y203/02013 ,  C12Y503/04001

摘要： A process for the preparation of a beverage, a beverage base, a beverage concentrate or a beverage additive having a reduced prolamin content from prolamin-containing raw materials, comprising the following steps: a) contacting the beverage or a precursor of the beverage with cross-linking enzymes to obtain modified prolamin; b) removing the modified prolamin at least partially.

摘要翻译： 一种用于制备饮酒，饮料基料，饮料浓缩物或具有从含醇溶蛋白原料中降低的醇溶蛋白含量的饮料添加剂的方法，包括以下步骤：a）使饮料或饮料的前体与十字 连接酶获得改性醇溶蛋白; b）至少部分地去除改性的醇溶醇。

公开(公告)号：US07858337B2

公开(公告)日：2010-12-28

申请号：US12074329

申请日：2008-03-03

申请人： Achim Müller ,  Monika Knuth ,  Katharina Schmid ,  Ralf Pasternack ,  Jens Zotzel ,  Kai Oertel ,  Christine Reiff, geb. Schmitt ,  Hans-Lothar Fuchsbauer

发明人： Achim Müller ,  Monika Knuth ,  Katharina Schmid ,  Ralf Pasternack ,  Jens Zotzel ,  Kai Oertel ,  Christine Reiff, geb. Schmitt ,  Hans-Lothar Fuchsbauer

IPC分类号： C07K7/00 ,  C12P1/00 ,  C12P21/04

CPC分类号： C08J7/047 ,  A61F2/14 ,  A61L27/28 ,  A61L27/34 ,  A61L27/50 ,  C08J2489/00 ,  G02C7/04 ,  C08L89/00

摘要： The invention relates to a process for the manufacture of a composite materials comprising the steps of (a) providing a hydrophobic organic bulk material, and (b) applying a hydrophilic surface coating on the hydrophobic organic bulk material by first non-covalently attaching to the surface of the bulk material a water-soluble peptide comprising a hydrophobic moiety; and then chemically or enzymatically crosslinking the water-soluble peptide. The composite materials manufactured according to the process of the invention have desirable characteristics regarding adherence to the substrate, durability, hydrophilicity, wettability, biocompatibility and permeability and are thus particularly useful as ophthalmic devices.

摘要翻译： 本发明涉及一种制备复合材料的方法，包括以下步骤：（a）提供疏水性有机体材料，和（b）通过首先非共价连接到疏水性有机大块材料 本体材料的表面是包含疏水部分的水溶性肽; 然后化学或酶促交联水溶性肽。 根据本发明的方法制造的复合材料具有关于对基材的粘附性，耐久性，亲水性，润湿性，生物相容性和渗透性的期望特性，因此特别适用于眼科装置。

公开(公告)号：US20050124036A1

公开(公告)日：2005-06-09

申请号：US10503910

申请日：2003-02-06

申请人： Rudy Susilo ,  Hans Korting ,  Hans Gassen ,  Martin Hils ,  Ralf Pasternack

发明人： Rudy Susilo ,  Hans Korting ,  Hans Gassen ,  Martin Hils ,  Ralf Pasternack

IPC分类号： C12N15/09 ,  A61K9/06 ,  A61K9/70 ,  A61K31/616 ,  A61K31/727 ,  A61K38/43 ,  A61K38/48 ,  A61K45/00 ,  A61P7/00 ,  A61P7/02 ,  A61P9/00 ,  A61P9/10 ,  A61P17/02 ,  A61P27/02 ,  C08B37/10 ,  C12N1/15 ,  C12N1/19 ,  C12N9/68 ,  C12N15/57 ,  C12N15/62 ,  C12Q1/37 ,  C07H21/04 ,  C12N1/18 ,  C12N9/48 ,  C12N15/74 ,  C12P21/04

CPC分类号： C12N9/6435 ,  C07K2319/02 ,  C12N15/62 ,  C12Y304/21007

摘要： The invention relates to a method for producing a recombinant functional plasminogen in micro-organisms, and to a method for identifying plasminogen activators. The nucleic acid sequence coding for the fuctional part of the plasminogen is fused with a nucleic acid molecule coding for at least one signal peptide. The nucleic acid molecule coding for the plasminogen and the nucleic acid molecule coding for the signal peptide are combined with codons for interfaces of proteases which ensure the separation of the signal peptide. The recombinant plasminogen or the corresponding plasmin is suitable for treating wounds which are slow to heal or not healing, by application of the enzyme in an appropriate formulation.

摘要翻译： 本发明涉及一种用于在微生物中产生重组功能性纤溶酶原的方法和一种鉴定纤溶酶原激活物的方法。 编码纤溶酶原功能部分的核酸序列与编码至少一个信号肽的核酸分子融合。 编码纤溶酶原的核酸分子和编码信号肽的核酸分子与保证信号肽分离的蛋白酶界面的密码子组合。 重组纤溶酶原或相应的纤溶酶适合于通过在合适的制剂中施用酶来治疗慢愈合或不愈合的伤口。

公开(公告)号：US20120315262A1

公开(公告)日：2012-12-13

申请号：US13509225

申请日：2010-11-11

申请人： Martin Hils ,  Ralf Pasternack ,  Johannes Weber

发明人： Martin Hils ,  Ralf Pasternack ,  Johannes Weber

IPC分类号： C12N9/10 ,  A61K38/45 ,  A61P25/08 ,  A61P29/00 ,  A61P19/02 ,  A61P25/00 ,  G01N33/566 ,  A61P1/16

CPC分类号： G01N33/564 ,  C12Q1/52 ,  G01N2333/91085

摘要： The present invention relates to the diagnosis of disorders or dysfunctions characterized by autoimmune responses to the enzyme class of transglutaminases. The present invention provides a novel open structure of the transglutaminases in a stabilized form which renders new epitopes accessible for antibody-binding.

摘要翻译： 本发明涉及特征在于对转谷氨酰胺酶类的自身免疫应答的病症或功能障碍的诊断。 本发明提供了稳定形式的转谷氨酰胺酶的新型开放结构，其使新的抗原决定簇可用于抗体结合。