发明申请
US20050148012A1 BPC-1: a secreted brain-specific protein expressed and secreted by prostate and bladder cancer cells
有权
BPC-1：由前列腺和膀胱癌细胞表达和分泌的分泌的脑特异性蛋白
- 专利标题： BPC-1: a secreted brain-specific protein expressed and secreted by prostate and bladder cancer cells
- 专利标题（中）： BPC-1：由前列腺和膀胱癌细胞表达和分泌的分泌的脑特异性蛋白
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申请号： US11061341申请日： 2005-02-18
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公开(公告)号： US20050148012A1公开(公告)日： 2005-07-07
- 发明人: Daniel Afar , Rene Hubert , Kahan Leong , Arthur Raitano , Douglas Saffran , Aya Jakobovits
- 申请人： Daniel Afar , Rene Hubert , Kahan Leong , Arthur Raitano , Douglas Saffran , Aya Jakobovits
- 主分类号： G01N33/493
- IPC分类号： G01N33/493 ; A61K31/7088 ; A61K31/7105 ; A61K39/00 ; A61K39/385 ; A61K39/395 ; A61K48/00 ; A61P13/08 ; A61P13/10 ; A61P35/00 ; C07K14/47 ; C07K16/18 ; C12N1/15 ; C12N1/19 ; C12N1/21 ; C12N5/10 ; C12N15/09 ; C12N15/12 ; C12P21/02 ; C12P21/08 ; C12Q1/68 ; C12R1/91 ; G01N33/50 ; G01N33/53 ; C07K16/30 ; C07K16/46 ; G01N33/574
摘要：
Described is a novel gene and its encoded secreted tumor antigen, termed BPC-1, and to diagnostic and therapeutic methods and compositions useful in the management of various cancers which express BPC-1, particularly including prostate cancer and bladder cancer. In human normal tissues, BPC-1 is only expressed in certain tissues of the brain. However, BPC-1 is expressed at high levels in prostate cancer cells and is also expressed in bladder cancer cells. The structure of BPC-1 includes a signal sequence and a CUB domain. BPC-1 protein is secreted. Preliminary experimental evidence suggests that BPC-1 is directly involved in oncogenesis or maintenance of the transformed phenotype of cancer cells expressing BPC-1. BPC-1 also appears to bind specifically to a cellular protein expressed in prostate cancer cells and other cells.