发明申请
US20050169965A1 Compounds with improved cartilage-inducing and/or bone-inducing activity
失效
具有改善的软骨诱导和/或骨诱导活性的化合物
- 专利标题： Compounds with improved cartilage-inducing and/or bone-inducing activity
- 专利标题（中）： 具有改善的软骨诱导和/或骨诱导活性的化合物
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申请号： US11080494申请日： 2005-03-16
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公开(公告)号： US20050169965A1公开(公告)日： 2005-08-04
- 发明人: Michael Paulista , Jens Pohl , Joachim Pabst , Helmut Heide
- 申请人： Michael Paulista , Jens Pohl , Joachim Pabst , Helmut Heide
- 申请人地址： DE Heidelberg
- 专利权人： Biopharm Gesellschaft zur biotechnologischen Entwicklung von Pharmaka mbH
- 当前专利权人： Biopharm Gesellschaft zur biotechnologischen Entwicklung von Pharmaka mbH
- 当前专利权人地址： DE Heidelberg
- 优先权： DE19647853.7 19961119
- 主分类号： C12N15/09
- IPC分类号： C12N15/09 ; A61K38/00 ; A61K38/18 ; A61L27/00 ; A61L27/22 ; A61L27/42 ; C07K14/495 ; C07K14/51 ; C07K19/00 ; A61K38/17 ; A61F2/00 ; A61K33/42
摘要：
The present invention concerns a bioactive implant material having a cartilage-inducing and/or bone-inducing activity composed of two components A and B, of which A is a bone-inducing and/or cartilage-inducing protein or protein mixture and preferably one or several proteins from the TGF-β superfamily, preferably MP52 or a DNA sequence coding therefor and B is a carrier matrix composed of calcium phosphate ceramics with an interconnecting microporosity which already alone has bone-inducing properties. The invention additionally concerns the production of these compounds and their use for the treatment of diseases which affect cartilage and/or bones as well as to treat damage to cartilage and/or bone tissue.