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    Compounds with improved cartilage-inducing and/or bone-inducing activity
    1.
    发明申请
    Compounds with improved cartilage-inducing and/or bone-inducing activity 失效
    具有改善的软骨诱导和/或骨诱导活性的化合物

    公开(公告)号：US20050169965A1

    公开(公告)日：2005-08-04

    申请号：US11080494

    申请日：2005-03-16

    申请人： Michael Paulista ,  Jens Pohl ,  Joachim Pabst ,  Helmut Heide

    发明人： Michael Paulista ,  Jens Pohl ,  Joachim Pabst ,  Helmut Heide

    IPC分类号： C12N15/09 ,  A61K38/00 ,  A61K38/18 ,  A61L27/00 ,  A61L27/22 ,  A61L27/42 ,  C07K14/495 ,  C07K14/51 ,  C07K19/00 ,  A61K38/17 ,  A61F2/00 ,  A61K33/42

    CPC分类号： A61L27/425 ,  A61K38/1875 ,  A61L27/227 ,  C07K14/495 ,  C07K14/51

    摘要： The present invention concerns a bioactive implant material having a cartilage-inducing and/or bone-inducing activity composed of two components A and B, of which A is a bone-inducing and/or cartilage-inducing protein or protein mixture and preferably one or several proteins from the TGF-β superfamily, preferably MP52 or a DNA sequence coding therefor and B is a carrier matrix composed of calcium phosphate ceramics with an interconnecting microporosity which already alone has bone-inducing properties. The invention additionally concerns the production of these compounds and their use for the treatment of diseases which affect cartilage and/or bones as well as to treat damage to cartilage and/or bone tissue.

    摘要翻译： 本发明涉及具有由两种组分A和B组成的软骨诱导和/或骨诱导活性的生物活性植入材料，其中A是诱导骨诱导和/或软骨诱导蛋白或蛋白质混合物，优选其中一种或 来自TGF-β超家族的几种蛋白质，优选MP52或其编码的DNA序列，B是由磷酸钙陶瓷构成的载体基质，其具有已经单独具有骨诱导性质的互连微孔。 本发明还涉及这些化合物的生产及其用于治疗影响软骨和/或骨骼的疾病以及治疗软骨和/或骨组织损伤的用途。

    Compounds with improved cartilage-inducing and/or bone-inducing activity
    2.
    发明授权
    Compounds with improved cartilage-inducing and/or bone-inducing activity 失效
    具有改善的软骨诱导和/或骨诱导活性的化合物

    公开(公告)号：US07365051B2

    公开(公告)日：2008-04-29

    申请号：US11080494

    申请日：2005-03-16

    申请人： Michael Paulista ,  Jens Pohl ,  Joachim Pabst ,  Helmut Heide

    发明人： Michael Paulista ,  Jens Pohl ,  Joachim Pabst ,  Helmut Heide

    IPC分类号： A61K38/00 ,  A61K9/14 ,  C07K1/00 ,  A61F2/00 ,  A61F3/00

    CPC分类号： A61L27/425 ,  A61K38/1875 ,  A61L27/227 ,  C07K14/495 ,  C07K14/51

    摘要： The present invention concerns a bioactive implant material having a cartilage-inducing and/or bone-inducing activity composed of two components A and B, of which A is a bone-inducing and/or cartilage-inducing protein or protein mixture and preferably one or several proteins from the TGF-β superfamily, preferably MP52 or a DNA sequence coding therefor and B is a carrier matrix composed of calcium phosphate ceramics with an interconnecting microporosity which already alone has bone-inducing properties. The invention additionally concerns the production of these compounds and their use for the treatment of diseases which affect cartilage and/or bones as well as to treat damage to cartilage and/or bone tissue.

    摘要翻译： 本发明涉及具有由两种组分A和B组成的软骨诱导和/或骨诱导活性的生物活性植入材料，其中A是诱导骨诱导和/或软骨诱导蛋白或蛋白质混合物，优选其中一种或 来自TGF-β超家族的几种蛋白质，优选MP52或其编码的DNA序列，B是由磷酸钙陶瓷构成的载体基质，其具有已经单独具有骨诱导性质的互连微孔。 本发明还涉及这些化合物的生产及其用于治疗影响软骨和/或骨骼的疾病以及治疗软骨和/或骨组织损伤的用途。

    Use of MP52 or MP121 for treating and preventing diseases of the nervous system
    6.
    发明授权
    Use of MP52 or MP121 for treating and preventing diseases of the nervous system 失效
    使用MP52或MP121治疗和预防神经系统疾病

    公开(公告)号：US06531450B2

    公开(公告)日：2003-03-11

    申请号：US08981490

    申请日：1998-05-18

    申请人： Gertrud Hötten ,  Jens Pohl ,  Rolf Bechtold ,  Michael Paulista ,  Klaus Unsicker

    发明人： Gertrud Hötten ,  Jens Pohl ,  Rolf Bechtold ,  Michael Paulista ,  Klaus Unsicker

    IPC分类号： A61R3818

    CPC分类号： C07K14/475 ,  A61K38/1841 ,  C07K2319/00 ,  A61K2300/00

    摘要： The present invention concerns the use of biologically active MP52 or/and MP121 for the treatment and prevention of diseases of the nervous system or/and for the treatment of neuropathological situations which are caused by ageing of the nervous system. A pharmaceutical agent according to the invention for the treatment and prevention of diseases of the nervous system or/and for treating neuropathological situations which are caused by ageing of the nervous system therefore contains biologically active MP52 or/and MP121 as the active substance.

    摘要翻译： 本发明涉及生物活性MP52或/和MP121用于治疗和预防神经系统疾病和/或用于治疗由神经系统衰老引起的神经病理学情况的用途。 因此，根据本发明的用于治疗和预防由神经系统衰老引起的神经系统疾病和/或用于治疗神经病理学情况的本发明的药剂包含生物活性MP52或/和MP121作为活性物质。