发明申请
US20050261228A1 Antisense modulation of interleukin 12 P35 subunit expression
审中-公开
白细胞介素12 P35亚基表达的反义调制
- 专利标题： Antisense modulation of interleukin 12 P35 subunit expression
- 专利标题（中）： 白细胞介素12 P35亚基表达的反义调制
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申请号： US11089191申请日： 2005-03-23
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公开(公告)号： US20050261228A1公开(公告)日： 2005-11-24
- 发明人: C. Bennett , Brenda Baker , Susan Freier , Susan Gregory , Ronnie Hanecak , Kevin Anderson , Ming-Yi Chiang , Vickie Brown-Driver , David Ecker , Timothy Vickers , Jacqueline Wyatt , Eric Marcusson , Nicholas Dean , Sanjay Bhanot , Elizabeth Ackermann , Lex Cowsert
- 申请人： C. Bennett , Brenda Baker , Susan Freier , Susan Gregory , Ronnie Hanecak , Kevin Anderson , Ming-Yi Chiang , Vickie Brown-Driver , David Ecker , Timothy Vickers , Jacqueline Wyatt , Eric Marcusson , Nicholas Dean , Sanjay Bhanot , Elizabeth Ackermann , Lex Cowsert
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; A61K48/00 ; C07H21/04 ; C12N15/113 ; C12N15/85
摘要：
Compounds, compositions and methods are provided for modulating the expression of Interleukin 12 p35 subunit. The compositions comprise chemically modified antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Interleukin 12 p35 subunit. Methods of using these compounds for modulation of Interleukin 12 p35 subunit expression and for treatment of diseases associated with expression of Interleukin 12 p35 subunit are provided.
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