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发明申请
US20050261290A1 Novel compounds of proline and morpholine derivatives 审中-公开
脯氨酸和吗啉衍生物的新型化合物

Novel compounds of proline and morpholine derivatives
摘要：
The present invention relates to compounds with the formulas (I), (II), and (III), or a pharmaceutically acceptable salt thereof: wherein T is a (4 to 10)-membered heterocyclyl selected from the group consisting of and wherein R1, R2 and R3 are as defined in the specification. The invention also relates to pharmaceutical compositions comprising the compounds of formulas (I), (II), and (III) and methods of treating a condition that is mediated by the modulation of the 11-β-hsd-1 enzyme, the method comprising administering to a mammal an effective amount of a compound of formulas (I), (II), and (III).
摘要（中）：

本发明涉及具有式（I），（II）和（III）的化合物或其药学上可接受的盐：其中T是选自下组的（4至10）元素的杂环基，其中R R 1，R 2和R 3如说明书中所定义。 本发明还涉及包含式（I），（II）和（III）化合物的药物组合物和治疗由11-β-hsd-1酶的调节介导的病症的方法，所述方法包括 向哺乳动物施用有效量的式（I），（II）和（III）的化合物。

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