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公开(公告)号：US20230044979A1
公开(公告)日：2023-02-09
申请号：US17943792
申请日：2022-09-13
申请人： AJINOMOTO CO., INC.
发明人： Seiichi Sato , Yuki Akeda , Yuta Endo , Ayana Matsuba , Chihiro Tsuji
IPC分类号： C12N5/00 , C07D277/06
摘要： A method for producing an objective protein by using animal cells as an expression host is provided. The objective protein is produced by culturing animal cells having an objective protein-producing ability in the presence of an L-cysteine derivative such as (2RS,4R)-2-methyl-2,4-thiazolidinedicarboxylic acid 2-ethyl ester.
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公开(公告)号：US20220259164A1
公开(公告)日：2022-08-18
申请号：US17618870
申请日：2020-06-13
发明人： Hongqi Tian , Yahong Liu
IPC分类号： C07D277/06 , C07C323/25 , A61P9/10 , A61P39/00 , C07D233/02
摘要： The present invention relates to the use of an aminothiol compound as a cerebral neuroprotective agent or a cardioprotective agent, especially the use in the prevention or treatment of cardio-cerebrovascular diseases, e.g., diseases such as cardio-cerebral ischemia reperfusion injury and stroke.
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公开(公告)号：US11123316B2
公开(公告)日：2021-09-21
申请号：US16843215
申请日：2020-04-08
IPC分类号： A61K31/18 , C07K17/06 , A61K51/10 , C07C259/06 , C07C309/14 , C07C311/19 , C07C311/29 , C07C311/42 , C07C311/46 , C07C323/60 , C07D207/48 , C07D211/60 , C07D211/96 , C07D213/42 , C07D213/74 , C07D213/89 , C07D215/36 , C07D223/06 , C07D277/06 , C07D277/80 , C07D279/12 , C07D295/13 , C07D309/06 , C07D401/12 , C07D405/12 , C07D413/12 , C07D453/06 , C07D471/08 , C07D487/08
摘要： The invention discussed in this application relates to hydroxamic acid-based compounds that are useful as imaging agents when bound to an appropriate metal centre, particularly for the imaging of tumours.
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公开(公告)号：US11072582B2
公开(公告)日：2021-07-27
申请号：US16929573
申请日：2020-07-15
申请人： Epics Therapeutics
发明人： Hamid R. Hoveyda , Didier Schils , Ludivine Zoute , Julien Parcq
IPC分类号： C07D295/10 , C07D207/16 , C07D277/06 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/10 , C07D403/14 , C07D405/10 , C07D407/06 , C07D409/10 , C07D413/10 , C07D413/12
摘要： The present invention is directed to novel compounds of formula (I) and their use in treating and/or preventing metabolic diseases.
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公开(公告)号：US10987317B2
公开(公告)日：2021-04-27
申请号：US16741635
申请日：2020-01-13
申请人： Cornell University
IPC分类号： A61K31/473 , A61K31/00 , C07D471/04 , C07D249/12 , C07D239/62 , C07D277/06 , C07D221/18 , A61K31/4745
摘要： The present invention relates to a method of reducing the production of glutamate from glutamine by glutaminase C in a cell or tissue. The method involves inhibiting glutaminase C activity in the cell or tissue under conditions effective to reduce production of glutamate from glutamine. Compounds for carrying out this method are also disclosed.
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公开(公告)号：US20200206149A1
公开(公告)日：2020-07-02
申请号：US16741635
申请日：2020-01-13
申请人： Cornell University
IPC分类号： A61K31/00 , C07D471/04 , C07D249/12 , C07D239/62 , C07D277/06 , C07D221/18 , A61K31/4745
摘要： The present invention relates to a method of reducing the production of glutamate from glutamine by glutaminase C in a cell or tissue. The method involves inhibiting glutaminase C activity in the cell or tissue under conditions effective to reduce production of glutamate from glutamine. Compounds for carrying out this method are also disclosed.
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公开(公告)号：US20180297944A1
公开(公告)日：2018-10-18
申请号：US16013281
申请日：2018-06-20
申请人： Ogeda SA
发明人： Hamid R. Hoveyda , Didier Schils , Ludivine Zoute , Julien Parcq
IPC分类号： C07D207/16 , C07D413/12 , C07D413/10 , C07D409/10 , C07D407/06 , C07D405/10 , C07D403/10 , C07D401/12 , C07D401/06 , C07D401/04 , C07D277/06 , C07D403/14
CPC分类号： C07D207/16 , C07D277/06 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/10 , C07D403/14 , C07D405/10 , C07D407/06 , C07D409/10 , C07D413/10 , C07D413/12
摘要： The present invention is directed to novel compounds of formula (I) and their use in treating and/or preventing metabolic diseases.
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8.发明申请公开(公告)号：US20180201591A1
公开(公告)日：2018-07-19
申请号：US15729046
申请日：2017-10-10
申请人： Merck Serono S.A.
发明人： Patrick Naxos PAGE , Matthias SCHWARZ , Catherine JORAND-LEBRUN , Anna QUATTROPANI , Vincent POMEL
IPC分类号： C07D277/06
CPC分类号： C07D277/06
摘要： The invention provides α-amino esters of a hydroxypropylthiazolidine carboxamide derivative, (2S)-3-([1,1′-biphenyl]-4-ylsulfonyl)-N-[(1S)-3-hydroxy-1-phenylpropyl]-1,3-thiazolidine-2-carboxamide, as well as salts and crystal polymorphs thereof, that can be used to inhibit prostaglandin F receptor. The invention further encompasses methods of treating disorders such as pre-term labor at the early gestational stage by the administration of these substances to a patient in need of treatment.
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公开(公告)号：US20170226070A1
公开(公告)日：2017-08-10
申请号：US15495496
申请日：2017-04-24
发明人： David RUBIN , Eyal RUBIN
IPC分类号： C07D277/06
CPC分类号： C07D277/06 , C07B2200/13 , C07D277/04
摘要： The present disclosure provides pharmaceutical compositions comprising Gamma-glutamyl cycle inhibitors (GGCI) and certain pharmaceutically acceptable salts thereof, and methods of use.
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公开(公告)号：US09717803B2
公开(公告)日：2017-08-01
申请号：US13725382
申请日：2012-12-21
发明人： Delphine Bregeon , Patrick Dennler , Christian Belmant , Eliane Fischer , Laurent Gauthier , Francois Romagné , Roger Schibli
IPC分类号： A61K47/48 , C07K16/00 , C07K16/30 , C07K19/00 , A61K31/5517 , C07C217/08 , C07C223/02 , C07C229/26 , C07C233/62 , C07C247/04 , C07C323/12 , C07C323/60 , C07D225/08 , C07D257/08 , C07D277/06 , C07F9/50 , C12N9/10 , C12P21/00 , G01N33/68
CPC分类号： A61K47/6803 , A61K47/60 , A61K47/68 , A61K47/6807 , A61K47/6813 , A61K47/6817 , A61K47/6865 , A61K47/6871 , C07C217/08 , C07C223/02 , C07C229/26 , C07C233/62 , C07C247/04 , C07C323/12 , C07C323/60 , C07D225/08 , C07D257/08 , C07D277/06 , C07F9/5022 , C07K16/00 , C07K19/00 , C07K2317/40 , C12N9/1044 , C12P21/005 , G01N33/6854
摘要： The present application relates to methods for the functionalization of immunoglobulins, in particular with drugs. Also disclosed herein are linking reagents, functionalized antibodies, pharmaceutical compositions, and method of treating disease and/or conditions.
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