- 专利标题： Analogs of benzoquinone-containing ansamycins and methods of use thereof
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申请号： US11107404申请日： 2005-04-14
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公开(公告)号： US20050288269A1公开(公告)日： 2005-12-29
- 发明人: Julian Adams , Yun Gao , Asimina Georges Evangelinos , Louis Grenier , Roger Pak , James Porter , James Wright
- 申请人： Julian Adams , Yun Gao , Asimina Georges Evangelinos , Louis Grenier , Roger Pak , James Porter , James Wright
- 主分类号： C07D211/60
- IPC分类号： C07D211/60 ; C07D225/06 ; C07D498/08 ; C07F5/02 ; C07F9/6561 ; A61K31/33 ; C07D225/04
摘要：
The present invention provides analogs of benzoquinone-containing ansamycins and uses thereof for treating and modulating disorders associated with hyperproliferation, such as cancer. The present invention provides analogs of benzoquinone-containing ansamycins where the benzoquinone is reduced to a hydroquinone and trapped by reaction with a suitable acid, preferably ones that increase the solubility and air stability of the resulting 17-ammonium hydroquinone ansamycin analog.
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