公开(公告)号：US09308179B2

公开(公告)日：2016-04-12

申请号：US13556647

申请日：2012-07-24

Applicant: Stephen E. Zale ,  Greg Troiano ,  Mir M. Ali ,  Jeff Hrkach ,  James Wright

Inventor： Stephen E. Zale ,  Greg Troiano ,  Mir M. Ali ,  Jeff Hrkach ,  James Wright

IPC: A61K9/51 ,  A61K47/34 ,  B82Y5/00 ,  A61K9/00 ,  A61K47/48

CPC classification number: A61K9/5153 ,  A61K9/0019 ,  A61K9/1641 ,  A61K31/337 ,  A61K31/436 ,  A61K31/475 ,  A61K31/519 ,  A61K47/542 ,  A61K47/593 ,  A61K47/60 ,  A61K47/6925 ,  A61K47/6937 ,  B82Y5/00

Abstract: The present disclosure is directed in part to a biocompatible nanoparticle composition comprising a plurality of non-colloidal long circulating nanoparticles, each comprising a α-hydroxy polyester-co-polyether and a therapeutic agent, wherein such disclosed compositions provide a therapeutic effect for at least 12 hours.

公开(公告)号：US08600060B2

公开(公告)日：2013-12-03

申请号：US12373874

申请日：2007-07-13

Applicant: Mark Priestley ,  Timothy James Wright ,  Caroline Jessica Belrose ,  Nicholas Bone ,  James Irwin

Inventor： Mark Priestley ,  Timothy James Wright ,  Caroline Jessica Belrose ,  Nicholas Bone ,  James Irwin

IPC: H04L9/08

CPC classification number: G06F21/10 ,  H04L63/20 ,  H04L67/125 ,  H04L67/34 ,  H04L2463/101 ,  H04W12/00 ,  H04W12/02 ,  H04W12/04

Abstract: A mobile terminal for use with a cellular or mobile telecommunications network includes a normal execution environment (operating system) (30) and a secure execution environment (32) comprising a Mobile Trusted Module (MTM). The mobile terminal enables the software of the terminal in the secure execution environment (32) to be updated. The terminal 1 may be provided with minimal software initially in the secure execution environment (32), and is operable to subsequently update the software by over the air transmission of software. Also disclosed is a method for managing rights in respect of broadcast, multicast and/or unicast (downloaded) data, relevant in particular to managing access to a broadcast video data stream complying with a mobile digital broadcast scheme. The method defines a service protection platform implemented on mobile terminals having both normal execution environment (i.e. the operating system) and secure execution environment. Service protection is provided by separating the operation of service protection application components into those that operate in the normal environment and those that are adapted to execute only in the secure execution environment. Making the secure execution environment application component interchangeable allows the method to be adapted to any of a number of service protection protocols or “profiles” by downloading only the secure execution environment application component.

Abstract translation: 用于蜂窝或移动电信网络的移动终端包括包括移动可信模块（MTM）的正常执行环境（操作系统）（30）和安全执行环境（32）。 移动终端使安全执行环境（32）中的终端的软件更新。 终端1可以最初在安全执行环境（32）中提供最小的软件，并且可操作以随后通过软件的空中传输更新软件。 还公开了一种用于管理关于广播，多播和/或单播（下载）数据的权利的方法，特别涉及管理对符合移动数字广播方案的广播视频数据流的访问。 该方法定义了在具有正常执行环境（即操作系统）和安全执行环境的移动终端上实现的服务保护平台。 通过将服务保护应用组件的操作分为在正常环境中操作的操作和仅在安全执行环境中执行的组件的操作来提供服务保护。 使安全执行环境应用程序组件可互换允许通过仅下载安全执行环境应用程序组件来将该方法适用于许多服务保护协议或“配置文件”中的任意一种。

公开(公告)号：US08518963B2

公开(公告)日：2013-08-27

申请号：US13372036

申请日：2012-02-13

Applicant: Mir Mukkaram Ali ,  Abhimanyu Sabnis ,  David Dewitt ,  Greg Troiano ,  James Wright ,  Maria Figueiredo ,  Michael Figa ,  Christina Van Geen Hoven ,  Young-Ho Song ,  Jason Auer ,  Tarikh Christopher Campbell

Inventor： Mir Mukkaram Ali ,  Abhimanyu Sabnis ,  David Dewitt ,  Greg Troiano ,  James Wright ,  Maria Figueiredo ,  Michael Figa ,  Christina Van Geen Hoven ,  Young-Ho Song ,  Jason Auer ,  Tarikh Christopher Campbell

IPC: A61K9/50 ,  A61K31/44

CPC classification number: G01N25/4866 ,  A61K9/0019 ,  A61K9/146 ,  A61K9/5153 ,  A61K31/00 ,  A61K31/337 ,  A61K31/427 ,  A61K31/436 ,  A61K31/475 ,  A61K31/573 ,  A61K31/58 ,  A61K31/585 ,  A61K31/69 ,  A61K47/34

Abstract: The present disclosure relates in part to pharmaceutical compositions comprising polymeric nanoparticles having certain glass transition temperatures. Other aspects of the invention include methods of making such nanoparticles.

Abstract translation: 本公开部分涉及包含具有某些玻璃化转变温度的聚合物纳米颗粒的药物组合物。 本发明的其它方面包括制备这种纳米颗粒的方法。

公开(公告)号：US20130023898A9

公开(公告)日：2013-01-24

申请号：US12173963

申请日：2008-07-16

Applicant: Yulun Wang ,  Modjtaba Ghodoussi ,  Darrin Uecker ,  James Wright ,  Amante Mangaser ,  Ranjan Mukherjee

Inventor： Yulun Wang ,  Modjtaba Ghodoussi ,  Darrin Uecker ,  James Wright ,  Amante Mangaser ,  Ranjan Mukherjee

IPC: A61B19/00

CPC classification number: G09B23/28 ,  A61B34/30 ,  A61B34/35 ,  A61B34/37 ,  A61B34/70 ,  A61B34/76 ,  A61B34/77 ,  A61B90/06 ,  A61B90/361 ,  A61B2017/00707 ,  A61B2034/305 ,  A61B2090/064 ,  G05B15/02 ,  G06F19/00 ,  G06F19/3418

Abstract: A medical system that allows a mentor to teach a pupil how to use a robotically controlled medical instrument. The system may include a first handle that can be controlled by a mentor to move the medical instrument. The system may further have a second handle that can be moved by a pupil to control the same instrument. Deviations between movement of the handles by the mentor and the pupil can be provided as force feedback to the pupil and mentor handles. The force feedback pushes the pupil's hand to correspond with the mentor's handle movement. The force feedback will also push the mentor's hand to provide information to the mentor on pupil's movements. The mentor is thus able to guide the pupil's hands through force feedback of the pupil handles to teach the pupil how to use the system.

公开(公告)号：US08318211B2

公开(公告)日：2012-11-27

申请号：US12485467

申请日：2009-06-16

Applicant: Stephen E. Zale ,  Greg Troiano ,  Mir Mukkaram Ali ,  Jeff Hrkach ,  James Wright

Inventor： Stephen E. Zale ,  Greg Troiano ,  Mir Mukkaram Ali ,  Jeff Hrkach ,  James Wright

IPC: A61K9/50 ,  A61K31/44 ,  A01N43/42

CPC classification number: A61K9/1647 ,  A61K9/14 ,  A61K9/1694 ,  A61K9/19 ,  A61K9/5153 ,  A61K31/4745 ,  A61K31/475 ,  A61K31/55 ,  A61K47/26

Abstract: The present disclosure generally relates to therapeutic nanoparticles. Exemplary nanoparticles disclosed herein may include about 1 to about 20 weight percent of a vinca alkaloid; and about 50 to about 99 weight percent biocompatible polymer.

Abstract translation: 本公开一般涉及治疗性纳米颗粒。 本文公开的示例性纳米颗粒可包括约1至约20重量％的长春花生物碱; 和约50至约99重量％的生物相容性聚合物。

公开(公告)号：US20120288541A1

公开(公告)日：2012-11-15

申请号：US13553210

申请日：2012-07-19

Applicant: Stephen E. Zale ,  Greg Troiano ,  Mir Mukkaram Ali ,  Jeff Hrkach ,  James Wright

Inventor： Stephen E. Zale ,  Greg Troiano ,  Mir Mukkaram Ali ,  Jeff Hrkach ,  James Wright

IPC: A61K9/14 ,  A61P35/00 ,  A61K31/337 ,  B82Y5/00

CPC classification number: A61K47/34 ,  A61J3/00 ,  A61K9/10 ,  A61K9/107 ,  A61K9/1647 ,  A61K9/19 ,  A61K9/5146 ,  A61K9/5153 ,  A61K31/337 ,  A61K31/4355 ,  A61K31/436 ,  A61K31/437 ,  A61K31/439 ,  A61K31/475 ,  A61K31/704 ,  A61K31/7068 ,  A61K47/6915 ,  A61K47/6925 ,  A61K47/6937 ,  B82Y5/00 ,  C07C59/08 ,  Y10S977/773

Abstract: The present disclosure generally relates to nanoparticles having about 0.2 to about 35 weight percent of a therapeutic agent; and about 10 to about 99 weight percent of biocompatible polymer such as a diblock poly(lactic) acid-poly(ethylene)glycol. Other aspects of the invention include methods of making such nanoparticles.

Abstract translation: 本公开内容通常涉及具有约0.2至约35重量％的治疗剂的纳米颗粒; 和约10至约99重量％的生物相容性聚合物，例如二嵌段聚（乳酸） - 聚（乙烯）二醇。 本发明的其它方面包括制备这种纳米颗粒的方法。

公开(公告)号：US07785320B2

公开(公告)日：2010-08-31

申请号：US12051957

申请日：2008-03-20

Applicant: Yulun Wang ,  Darrin R Uecker ,  Jeff Wilson ,  Keith Philip Laby ,  Steve Jordan ,  James Wright

Inventor： Yulun Wang ,  Darrin R Uecker ,  Jeff Wilson ,  Keith Philip Laby ,  Steve Jordan ,  James Wright

IPC: A61B17/00

CPC classification number: A61B17/11 ,  A61B17/0469 ,  A61B17/29 ,  A61B34/30 ,  A61B34/35 ,  A61B34/37 ,  A61B34/70 ,  A61B34/71 ,  A61B34/72 ,  A61B34/75 ,  A61B34/76 ,  A61B34/77 ,  A61B46/10 ,  A61B50/00 ,  A61B90/361 ,  A61B2017/00199 ,  A61B2017/00243 ,  A61B2017/00252 ,  A61B2017/0046 ,  A61B2017/00477 ,  A61B2017/00703 ,  A61B2017/00973 ,  A61B2017/1107 ,  A61B2017/1135 ,  A61B2017/2927 ,  A61B2017/2929 ,  A61B2034/2059 ,  A61B2034/742 ,  A61B2090/064 ,  B25J9/1689 ,  G05B2219/45119

Abstract: A system for performing minimally invasive cardiac procedures. The system includes a pair of surgical instruments that are coupled to a pair of robotic arms. The instruments have end effectors that can be manipulated to hold and suture tissue. The robotic arms are coupled to pair of master handles by a controller. The handles can be moved by the surgeon to produce a corresponding movement of the end effectors. The controller controls and limits movement of robotic arms relative to the patient.

Abstract translation: 用于执行微创心脏手术的系统。 该系统包括耦合到一对机器人臂的一对外科器械。 仪器具有能够被操纵以保持和缝合组织的末端效应器。 机器臂通过控制器耦合到一对主手柄。 手柄可由外科医生移动以产生末端执行器的相应运动。 控制器控制和限制机器人臂相对于患者的运动。

公开(公告)号：US20100216804A1

公开(公告)日：2010-08-26

申请号：US12638297

申请日：2009-12-15

Applicant: Stephen E. Zale ,  Greg Troiano ,  Mir M. Ali ,  Jeff Hrkach ,  James Wright ,  Susan Low

Inventor： Stephen E. Zale ,  Greg Troiano ,  Mir M. Ali ,  Jeff Hrkach ,  James Wright ,  Susan Low

IPC: A61K9/14 ,  A61K31/337 ,  A61K31/4745 ,  A61K31/519 ,  A61K31/436 ,  A61P35/00

CPC classification number: A61K9/5153 ,  A61K9/0019 ,  A61K9/1641 ,  A61K31/337 ,  A61K31/436 ,  A61K31/475 ,  A61K31/519 ,  A61K47/542 ,  A61K47/593 ,  A61K47/60 ,  A61K47/6925 ,  A61K47/6937 ,  B82Y5/00

Abstract: The present disclosure is directed in part to a biocompatible nanoparticle composition comprising a plurality of non-colloidal long circulating nanoparticles, each comprising a α-hydroxy polyester-co-polyether and a therapeutic agent, wherein such disclosed compositions provide a therapeutic effect for at least 12 hours.

Abstract translation: 本公开部分地涉及生物相容性纳米颗粒组合物，其包含多个非胶体长循环纳米颗粒，每个非胶体长循环纳米颗粒包含α-羟基聚酯 - 共聚醚和治疗剂，其中所述公开的组合物至少提供治疗效果 12小时。

公开(公告)号：US20090012544A1

公开(公告)日：2009-01-08

申请号：US12135989

申请日：2008-06-09

Applicant: Chris Thompson ,  Mitchell Roslin ,  Mitchell Dann ,  Greg Fluet ,  James Wright

Inventor： Chris Thompson ,  Mitchell Roslin ,  Mitchell Dann ,  Greg Fluet ,  James Wright

IPC: A61B17/11

CPC classification number: A61B17/1114 ,  A61B17/11 ,  A61B2017/00557 ,  A61B2017/0647 ,  A61F2002/045

Abstract: Disclosed herein are systems and methods for treating a patient that has undergone a bariatric surgical procedure, to promote weight loss in the patient. The systems and methods can involve positioning a gastrointestinal bypass sleeve within a portion of the altered GI anatomy to create or restore a restriction, and/or create a malabsorptive effect via a gastric and partial intestinal bypass. The bypass sleeve can include a proximal attachment element for attaching the proximal end of the sleeve in a penetrating or non-penetrating manner at the gastroesophageal junction, stomach, neo-stomach, or other locations. The bypass can be placed during the same operative session as the bariatric surgical procedure, or alternatively at a later date.

Abstract translation: 本文公开了用于治疗已经进行减肥手术的患者的系统和方法，以促进患者的体重减轻。 系统和方法可以包括将胃肠旁路套管定位在改变的GI解剖结构的一部分内以产生或恢复限制，和/或通过胃和部分肠旁路产生吸收不良的作用。 旁路套管可以包括用于以穿透或非穿透方式在胃食管接合部，胃，新胃或其他位置附接套筒的近端的近端附接元件。 旁路可以在与减肥手术相同的手术期间放置，或者在稍后的日期。

公开(公告)号：US20090012356A1

公开(公告)日：2009-01-08

申请号：US12137475

申请日：2008-06-11

Applicant: Mitchell Dann ,  Greg Fluet ,  James Wright ,  Terry Dahl ,  Gregg Sutton ,  Joshua Butters ,  Cole Chen

Inventor： Mitchell Dann ,  Greg Fluet ,  James Wright ,  Terry Dahl ,  Gregg Sutton ,  Joshua Butters ,  Cole Chen

IPC: A61B1/018 ,  A61M29/02

CPC classification number: A61B17/0401 ,  A61B2017/00278 ,  A61B2017/00889 ,  A61B2017/00893 ,  A61B2017/0409 ,  A61B2017/0412 ,  A61B2017/0464 ,  A61B2017/0496 ,  A61B2017/06052 ,  A61F5/0076 ,  A61M31/00

Abstract: Disclosed herein are various devices and methods that can be utilized independently or in conjunction with each other for endoscopic delivery of a wide ranges of medical devices, such as, for example, an endoscopic gastrointestinal bypass sleeve with an attachment cuff. Components of the system can include a space-creating device; an expandable fastener system with flower petal-shaped retention elements; and an endoscopic curved needle driver system.

Abstract translation: 本文公开了可以独立地或彼此结合使用的各种装置和方法，用于内窥镜递送各种医疗装置，例如具有附接袖带的内窥镜胃肠旁路套管。 系统的组件可以包括空间创建设备; 具有花瓣状保持元件的可扩张紧固件系统; 和内窥镜弯曲针驱动器系统。